PMID: 7536096Jan 1, 1995Paper

The role of nitric oxide in cardiac depression induced by interleukin-1 beta and tumour necrosis factor-alpha

British Journal of Pharmacology
R SchulzG D Lopaschuk

Abstract

1. Myocardial dysfunction during septic shock is associated with enhanced production of cytokines such as interleukin-1 beta (IL-1 beta) and tumour necrosis factor-alpha (TNF-alpha). These cytokines depress cardiac mechanical function by a mechanism which is not well defined. 2. Bacterial endotoxin or cytokines cause the expression of Ca(2+)-independent nitric oxide (NO) synthase in cardiac myocytes, vascular endothelial cells and endocardial endothelial cells, causing enhanced production of NO. As NO has negative inotropic actions on cardiac muscle, we tested the sum effects of IL-1 beta plus TNF-alpha in the intact heart to determine whether enhanced expression of NO synthase activity in the cells that comprise the heart is involved in cardiac depression associated with cytokine stimulation. 3. Rat isolated working hearts perfused with IL-1 beta plus TNF-alpha showed a markedly greater depression in contractile function, measured as cardiac work, after 2 h of perfusion compared with time-matched control hearts. The depressant action of IL-1 beta plus TNF-alpha was first apparent after 1 h of perfusion; no early (15 min) cardiac depressant actions were seen. 4. The competitive inhibitor of Ca(2+)-dependent and Ca(2+)-independe...Continue Reading

References

Jan 1, 1992·Cardiovascular Research·C E WrightS Moncada
Nov 1, 1990·British Journal of Pharmacology·D D ReesS Moncada
Aug 1, 1991·The Journal of Physiology·J A SmithM J Lewis
Sep 1, 1991·British Journal of Pharmacology·R SchulzS Moncada
Jun 1, 1990·Circulation Research·M Kelm, J Schrader
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R G KilbournR F Lodato
Sep 1, 1990·The Journal of Clinical Investigation·P A SobotkaJ X Thomas
Aug 3, 1989·The New England Journal of Medicine·A F SuffrediniJ E Parrillo
May 1, 1989·Chest·R E Cunnion, J E Parrillo
Jan 4, 1989·Journal of the National Cancer Institute·R NoraH J Silverman
Aug 1, 1966·The American Journal of Physiology·R T Solis, S E Downing
Mar 1, 1970·European Journal of Pharmacology·P J Kadowitz, A C Yard
Apr 1, 1967·The American Journal of Physiology·J R NeelyH E Morgan
Mar 15, 1980·The Biochemical Journal·H TaegtmeyerH A Krebs
Jan 9, 1993·Lancet·A J de BelderS Moncada
Jul 1, 1994·Trends in Pharmacological Sciences·R Schulz, C R Triggle
Jan 1, 1993·Annual Review of Cell Biology·K J Tracey, A Cerami
Jan 1, 1993·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·N Kobayashi
May 1, 1993·Trends in Cardiovascular Medicine·A M Shah, M J Lewis

❮ Previous
Next ❯

Citations

Oct 23, 1997·Clinical Cardiology·U Ikeda, K Shimada
Jul 29, 1999·Journal of Molecular and Cellular Cardiology·K SugishitaO Kohmoto
Jun 12, 2002·Journal of Molecular and Cellular Cardiology·Natsuya KeiraMasao Nakagawa
Jun 11, 2002·Journal of Molecular and Cellular Cardiology·Nanette H Bishopric
Dec 1, 1995·Giornale italiano di cardiologia·R J BingH Suzuki
May 30, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Marcin Bujak, Nikolaos G Frangogiannis
Sep 28, 2012·Journal of Cardiovascular Translational Research·Melissa L Martin, Burns C Blaxall
May 6, 1996·European Journal of Pharmacology·A N BatesonR Schulz
Jul 1, 1995·International Journal of Cardiology·S M WildhirtR J Bing
Jul 1, 1995·International Journal of Cardiology·A de Belder, S Moncada
May 1, 1997·Disease-a-month : DM·R G KilbournC Szabó
Jul 25, 2003·Journal of Molecular and Cellular Cardiology·Hiroshi HasegawaIssei Komuro
Apr 24, 2001·Pharmacology & Therapeutics·S K Wattanapitayakul, J A Bauer
Apr 13, 2000·Pharmacology & Therapeutics·A M Shah, P A MacCarthy
Mar 6, 1998·International Journal of Cardiology·A Matsumori
Mar 26, 1999·Journal of the American College of Cardiology·M FleschM Böhm
Jun 26, 1999·Journal of Critical Care·J L VincentG Friedman
Apr 25, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·E J BirksM H Yacoub
Sep 6, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mark L DaCostaValluvan Jeevanandam
Dec 1, 1996·Cytokine & Growth Factor Reviews·D L Mann
Apr 26, 2000·British Journal of Pharmacology·R G BogleP Vallance
Sep 29, 1998·Critical Care Medicine·O A StrandK A Kirkebøen
Aug 14, 1999·Critical Care Medicine·A KumarJ E Parrillo
May 29, 2003·Critical Care Medicine·Tiziana BachettiRoberto Ferrari
Sep 3, 2004·Critical Care Medicine·Steven M HollenbergSergio Zanotti-Cavazzoni
Dec 1, 1995·British Journal of Pharmacology·H NawrathH Oelert
Dec 19, 1998·Journal of Veterinary Internal Medicine·L M FreemanR Roubenoff
Dec 26, 2002·Annual Review of Physiology·Douglas L Mann
Oct 14, 1998·American Journal of Respiratory and Critical Care Medicine·B Y PoonK R Walley
Oct 13, 2011·Journal of Neuroinflammation·Janelle Drouin-OuelletFrancesca Cicchetti
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·B J PomerantzC A Dinarello
Feb 22, 2001·Journal of Molecular and Cellular Cardiology·T BachettiR Ferrari

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