The role of nitric oxide in facial motoneuronal death

Brain Research
R S RuanK H Yeoh

Abstract

The present study aimed to determine whether nitric oxide synthase (NOS)/nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) activity would be induced in facial motoneurons after facial nerve avulsion and if so, whether such activity was related to neuronal death commonly observed after such injury. The left facial nerve in each of 28 Wistar albino rats was avulsed from the facial canal. Ten of them received either daily injections of N omega-nitro-L-arginine methyl ether (L-NAME) or the vehicle. After survival times ranging from 2-50 days, serial brainstem sections were processed for NOS immunocytochemistry and NADPH-d histochemistry respectively. The number of surviving, NOS and NADPH-d positive and NOS negative neurons were compared statistically. Two days after facial nerve avulsion, increased NADPH-d activity was noticed in the facial motoneurons and in the endothelial lining of many dilated blood vessels in the facial motor nucleus (FMN). NOS-positive neurons were not detectable until five days after operation. Both the number and staining intensity of NADPH-d and NOS-positive neurons increased steadily with increasing survival time while the number of surviving neurons decreased after nerve avulsion. Daily a...Continue Reading

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Citations

Dec 24, 2005·Anatomy and Embryology·J CalkaM Lakomy
Dec 31, 2010·Molecular Neurobiology·Bernardo Moreno-LópezDavid González-Forero
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