The role of nitric oxide in modulating brain activity and blood flow during seizure

Neuroreport
M A TheardR F Albrecht

Abstract

The role played by nitric oxide (NO) in modulating seizure activity and cerebral blood flow (CBF) during seizures was investigated in rats. Seizures were induced with bicuculline (a GABA antagonist, 1.2 mg kg-1, i.v.). Each animal was subjected to an initial bicuculline-induced seizure followed by treatment with either L-nitroarginine (L-NA, a NO synthase inhibitor) or its less active enantiomer D-NA as a 50 mg kg-1 bolus followed by an infusion of 1 mg kg-1 min-1. The animals then received a second bicuculline treatment. Seizure duration was monitored using EEG and CBF was measured with laser-Doppler. There was no difference in seizure duration before or after D-NA administration. Seizure duration doubled from (6 +/- 1 to 12 +/- 2 min p < 0.05) following inhibition of NO synthase with L-NA. The increase in CBF that accompanied the seizure activity paralleled the seizure duration. Our data support the concept that (1) NO acts as an endogenous anticonvulsant, with seizure duration doubling when NO synthase is acutely inhibited, and (2) that NO is not the messenger that couples CBF to metabolism during bicuculline-induced seizures.

Citations

May 1, 1997·Biulleten' eksperimental'noĭ biologii i meditsiny·K S Raevskiĭ
Apr 20, 2000·European Journal of Pharmacology·G De SarroA De Sarro
Jul 23, 1997·European Journal of Pharmacology·K K BorowiczS J Czuczwar
Aug 9, 2003·Neuropharmacology·Shadpour DemehriAhmad Reza Dehpour
Jul 19, 2000·Pharmacology, Biochemistry, and Behavior·B Shi, J E Heavner
Feb 2, 2002·Epilepsy Research·Houman HomayounAhmad Reza Dehpour
Jun 28, 2014·Epilepsy & Behavior : E&B·Elahe SattarinezhadLeila Moezi
Mar 13, 2012·Epilepsy & Behavior : E&B·Leila MoeziAhmad Reza Dehpour
Jul 15, 2009·European Journal of Pharmacology·Taha GholipourAhmad Reza Dehpour
Aug 16, 2008·Epilepsy & Behavior : E&B·Taha GholipourAhmad Reza Dehpour
Feb 14, 2006·British Journal of Pharmacology·Kiarash RiaziAhmad Reza Dehpour
Mar 21, 2012·Fundamental & Clinical Pharmacology·Kasra MoazzamiMohammad Shabani
Jan 13, 2006·Epilepsy Research·Noushin Yahyavi-Firouz-AbadiAhmad Reza Dehpour
Aug 23, 2012·Neurological Research·Hamed ShafaroodiAhmad Reza Dehpour
Nov 28, 2009·Seizure : the Journal of the British Epilepsy Association·Taha GholipourAhmad Reza Dehpour
Feb 13, 2010·Seizure : the Journal of the British Epilepsy Association·Jinzhi LiuAijun Hao
Oct 4, 2012·Seizure : the Journal of the British Epilepsy Association·Bindu MenonRajendiran Vinoth Kumar
May 21, 2013·Physiology & Behavior·Borna PayandemehrAhmad Reza Dehpour
Jan 1, 2008·European Journal of Pharmacology·Taha GholipourAhmad Reza Dehpour
Aug 1, 1997·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E A Del-BelN Garcia-Cairasco
Oct 28, 2005·Human Molecular Genetics·Denia Ramirez-Montealegre, David A Pearce
Aug 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Pierluigi CarratuHelena Parfenova
Jun 13, 2018·Behavioral Sciences·Lourdes Lorigados PedreSandra Orozco-Suárez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.