The role of nitric oxide in mycobacterial infections.

Immune Network
Chul-Su YangEun-Kyeong Jo

Abstract

Although tuberculosis poses a significant health threat to the global population, it is a challenge to develop new and effective therapeutic strategies. Nitric oxide (NO) and inducible NO synthase (iNOS) are important in innate immune responses to various intracellular bacterial infections, including mycobacterial infections. It is generally recognized that reactive nitrogen intermediates play an effective role in host defense mechanisms against tuberculosis. In a murine model of tuberculosis, NO plays a crucial role in antimycobacterial activity; however, it is controversial whether NO is critically involved in host defense against Mycobacterium tuberculosis in humans. Here, we review the roles of NO in host defense against murine and human tuberculosis. We also discuss the specific roles of NO in the central nervous system and lung epithelial cells during mycobacterial infection. A greater understanding of these defense mechanisms in human tuberculosis will aid in the development of new strategies for the treatment of disease.

References

Aug 30, 1994·Biochemical and Biophysical Research Communications·R A RobbinsJ M Polak
Aug 1, 1994·The Journal of Infectious Diseases·P K PetersonC C Chao
May 1, 1996·The Journal of Experimental Medicine·S NicholsonJ L Ho
Jan 1, 1997·Annual Review of Immunology·J MacMickingC Nathan
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·J D MacMickingC F Nathan
Oct 6, 1997·The Journal of Clinical Investigation·C ZaragozaC J Lowenstein
Jan 20, 1998·Trends in Biochemical Sciences·B Mayer, B Hemmens
Jan 27, 1998·Journal of Korean Medical Science·O J Kwon
Feb 12, 1998·The American Journal of Physiology·J J PoderosoA Boveris
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·C ZaragozaC J Lowenstein
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·C AstonJ Reibman
Aug 6, 1998·Respirology : Official Journal of the Asian Pacific Society of Respirology·O J KwonC H Rhee
Sep 10, 1998·Nitric Oxide : Biology and Chemistry·C JagannathR L Hunter
Nov 10, 1998·The Biochemical Journal·G Wu, S M Morris
Jan 23, 1999·The American Journal of Pathology·F FacchettiR Badolato
Jan 1, 1997·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·L B AdamsJ L Krahenbuhl
Jan 1, 1997·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·E A RichZ Toossi
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·C Nathan, M U Shiloh
Jul 18, 2002·American Journal of Respiratory and Critical Care Medicine·Hyung-Seok ChoiEdward D Chan
Jan 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Takaaki AkaikeHiroshi Maeda
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paulo C RodriguezAugusto C Ochoa
May 4, 2004·Journal of Medical Virology·Gisela GambaFabian Benencia
Jul 28, 2004·The American Journal of Clinical Nutrition·Nicholas I PatonCynthia B E Chee
Jul 29, 2004·Journal of Virology·Jun YoshitakeHiroshi Maeda
Oct 19, 2004·Clinical Microbiology Reviews·R Bryan RockPhillip K Peterson

❮ Previous
Next ❯

Citations

Feb 22, 2013·BMC Microbiology·Marta BrzezinskaJaroslaw Dziadek
Sep 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·María A Duque-CorreaStephen T Reece
Aug 3, 2010·Pharmaceutical Biology·Camila B de A CarliIracilda Z Carlos
Aug 5, 2011·Immunobiology·Antima GuptaSanjib Bhakta
Jul 1, 2010·Cell Biochemistry and Function·Douglas Popp MarinRosemari Otton
Sep 12, 2015·Seminars in Immunology·Anthony J CovarrubiasTiffany Horng
Mar 5, 2016·The Journal of Allergy and Clinical Immunology·Francesca ContiJacinta Bustamante
May 9, 2016·Neuromolecular Medicine·William R FolkGrace Sun
Jul 8, 2016·Scientific Reports·Christophe J QuevalPriscille Brodin
Aug 11, 2016·European Journal of Medicinal Chemistry·Guilherme Felipe Dos Santos FernandesJean Leandro Dos Santos
Mar 4, 2017·Scientific Reports·Rachel TannerHelen McShane
Mar 23, 2018·Experimental Lung Research·Y López-HernándezR Hernandez-Pando
Jul 30, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonathan Braverman, Sarah A Stanley
Oct 15, 2018·Journal of Cellular Biochemistry·Ruchi ParohaRashmi Chourasia
Dec 8, 2019·Biological Chemistry·Constance PorriniSeav-Ly Tran
Mar 7, 2017·Frontiers in Immunology·Vidyullatha PeddireddyNiyaz Ahmed
Nov 1, 2017·Frontiers in Microbiology·Hamidreza JamaatiJohan Garssen
Apr 15, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hong Yien TanSuzanne M Crowe
Feb 27, 2018·Frontiers in Immunology·Susanta PahariJaved N Agrewala
Feb 11, 2021·Immunological Reviews·Gül KilinçMariëlle C Haks

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.