The role of nitric oxide in the acetylcholine-induced relaxation of the feline internal anal sphincter, in vitro

Scandinavian Journal of Gastroenterology
S BuntzenD Delbro

Abstract

The relaxatory effect of acetylcholine was investigated on the feline internal anal sphincter (IAS), in vitro. Acetylcholine (10, 30, 100, and 1000 microM) caused a concentration-dependent relaxation of the same magnitude in strips from the proximal and distal IAS. The antagonist of nitric oxide synthase, N omega-nitro-L-arginine (L-NNA; 1, 10, and 100 microM), in a concentration-dependent and stereospecific manner, blocked the acetylcholine-induced relaxation, leaving a residual response of 10-30%. The blocking effect of L-NNA (100 microM) could not be shown in tissues that had been incubated with the substrate for nitric oxide synthase, L-arginine (1 mM). The present results suggest that the acetylcholine-induced relaxation of the IAS to a major extent is due to an activation of nitrergic, inhibitory motor neurons to the IAS.

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Citations

Jun 24, 2009·International Journal of Colorectal Disease·Juliana TieppoNorma Possa Marroni
Feb 8, 2007·Diseases of the Colon and Rectum·Henrique Sarubbi FillmannNorma Possa Marroni
Sep 10, 2003·Autonomic Neuroscience : Basic & Clinical·Lars Börjesson, Dick S Delbro
Jul 17, 1999·Critical Reviews in Clinical Laboratory Sciences·R P Kapur
Apr 17, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N I KortezovaZ N Mizhorkova
Apr 20, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S Rattan
Oct 24, 2002·Diseases of the Colon and Rectum·N GriffinW R Schouten
Jan 20, 2021·Digestive Diseases and Sciences·Ji-Hong ChenJan D Huizinga
Jan 20, 2021·Digestive Diseases and Sciences·Ji-Hong ChenJan D Huizinga

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