PMID: 8962702Nov 1, 1995Paper

The role of nitric oxide in the control of protein secretion in the submandibular gland of the cat

Experimental Physiology
A D BuckleA V Edwards

Abstract

Submandibular salivary responses to stimulation of the parasympathetic chorda lingual innervation have been investigated in anaesthetized cats in the presence and absence of N omega-arginine-L-methyl ester (L-NAME) to block the synthesis of nitric oxide. Stimulation either at 2 Hz continuously or at 20 Hz for 1 s at 10 s intervals produced an abrupt fall in submandibular vascular resistance and initiated a flow of submandibular saliva. Neither of these responses differed significantly from the other but the output of protein was significantly potentiated (P < 0.05) when the high-frequency intermittent pattern of stimulation was employed. This potentiation of protein output was abolished in the presence of L-NAME, when the output of protein from the gland was closely similar, whichever pattern of stimulation was employed. Additional administration of atropine completely blocked all submandibular responses to parasympathetic stimulation showing that, in the presence of L-NAME, each response was due to release of acetylcholine acting on muscarinic receptors. The intermittent pattern of chorda lingual nerve stimulation produced a significant rise in the output of vasoactive intestinal peptide (VIP) from the gland (P < 0.01) and thi...Continue Reading

Citations

Jan 27, 2009·Micron : the International Research and Review Journal for Microscopy·A C IssyE A Del Bel
Sep 28, 2004·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Y YamamotoH Sugiya
Aug 13, 2002·Autonomic Neuroscience : Basic & Clinical·A P HarrisonA V Edwards
Nov 9, 2002·Autonomic Neuroscience : Basic & Clinical·Gunnar TobinBengt Götrick
Apr 2, 2016·International Journal of Dentistry·Maria de Lourdes BresegheloCláudio Rodrigues Leles
Dec 13, 2006·Autonomic Neuroscience : Basic & Clinical·Gordon B Proctor, Guy H Carpenter
Feb 16, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mohammad Abdollahi, Hajar Safarhamidi
Nov 4, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M AbdollahiP Kazemian
Jul 31, 2001·Autonomic Neuroscience : Basic & Clinical·Z J HalfacreeA V Edwards
Feb 15, 2002·Advances in Dental Research·D K LoomsB Nauntofte
Apr 10, 2003·Pflügers Archiv : European journal of physiology·Shoji TsunodaHiroshi Sugiya
Jan 19, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Omar R TumilasciJorge H Pazo
Jan 1, 2006·Toxicology Mechanisms and Methods·Abdollah Osman AhmedMohammad Abdollahi
Dec 3, 2005·Journal of Applied Physiology·G TobinA V Edwards
Jul 15, 2003·Journal of Applied Physiology·C M B EdwardsA V Edwards
Oct 31, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Dagnia LoomsSteen Dissing

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.