The Role of Nitroglycerin and Other Nitrogen Oxides in Cardiovascular Therapeutics

Journal of the American College of Cardiology
Sanjay Divakaran, Joseph Loscalzo

Abstract

The use of nitroglycerin in the treatment of angina pectoris began not long after its original synthesis in 1847. Since then, the discovery of nitric oxide as a biological effector and better understanding of its roles in vasodilation, cell permeability, platelet function, inflammation, and other vascular processes have advanced our knowledge of the hemodynamic (mostly mediated through vasodilation of capacitance and conductance arteries) and nonhemodynamic effects of organic nitrate therapy, via both nitric oxide-dependent and -independent mechanisms. Nitrates are rapidly absorbed from mucous membranes, the gastrointestinal tract, and the skin; thus, nitroglycerin is available in a number of preparations for delivery via several routes: oral tablets, sublingual tablets, buccal tablets, sublingual spray, transdermal ointment, and transdermal patch, as well as intravenous formulations. Organic nitrates are commonly used in the treatment of cardiovascular disease, but clinical data limit their use mostly to the treatment of angina. They are also used in the treatment of subsets of patients with heart failure and pulmonary hypertension. One major limitation of the use of nitrates is the development of tolerance. Although several a...Continue Reading

Citations

Sep 13, 2018·Experimental Biology and Medicine·Stephen J JonesPaul A Beales
Jan 25, 2020·British Journal of Pharmacology·Yuqin ChenJian Wang
Jun 10, 2020·Kardiologiia·O N TkachevaK A Eruslanova
Feb 8, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Claudio NapoliJoseph Loscalzo
Nov 30, 2019·Frontiers in Pharmacology·Natalia Pavlovna AkentievaSergei Michailovich Aldoshin
Jul 24, 2020·Journal of Applied Physiology·Jacky LautridouFrançois Guerrero
Feb 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tengshuo LuoZhonghua Yang
Aug 9, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Moon Sung KimKi Nam Lee
Sep 10, 2019·Anesthesiology and Pain Medicine·Farsad ImaniMohamadreza Khajavi
Aug 1, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Bingwu HuangNing Zhu
Oct 12, 2020·European Journal of Clinical Pharmacology·Kentaro UshijimaAkio Fujimura
Jan 16, 2021·British Journal of Pharmacology·Melina LopezFlávia Rezende
Feb 22, 2021·Current Hypertension Reports·Nicholas HarrisonPhillip Levy
Jul 30, 2020·Nitric Oxide : Biology and Chemistry·Peter C Ford, Katrina M Miranda
Apr 2, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jonas GronerMiriam Breunig
Jun 21, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chengdi LiuGuanhua Du
Jul 3, 2021·International Journal of Molecular Sciences·Alicja NowaczykGrzegorz Grześk

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