The Role of NLRP3 Inflammasome Activation in the Epithelial to Mesenchymal Transition Process During the Fibrosis.

Frontiers in Immunology
Amani Abraheem Alsadiq AlyaseerTarcio Teodoro Braga

Abstract

Fibrosis is considered a complex form of tissue damage commonly present in the end stage of many diseases. It is also related to a high percentage of death, whose predominant characteristics are an excessive and abnormal deposition of fibroblasts and myofibroblasts -derived extracellular matrix (ECM) components. Epithelial-to-mesenchymal transition (EMT), a process in which epithelial cells gradually change to mesenchymal ones, is a major contributor in the pathogenesis of fibrosis. The key mediator of EMT is a multifunctional cytokine called transforming growth factor-β (TGF-β) that acts as the main inducer of the ECM assembly and remodeling through the phosphorylation of Smad2/3, which ultimately forms a complex with Smad4 and translocates into the nucleus. On the other hand, the bone morphogenic protein-7 (BMP-7), a member of the TGF family, reverses EMT by directly counteracting TGF-β induced Smad-dependent cell signaling. NLRP3 (NACHT, LRR, and PYD domains-containing protein 3), in turn, acts as cytosolic sensors of microbial and self-derived molecules and forms an immune complex called inflammasome in the context of inflammatory commitments. NLRP3 inflammasome assembly is triggered by extracellular ATP, reactive oxygen sp...Continue Reading

References

Jan 1, 1991·Ciba Foundation Symposium·K Miyazono, C H Heldin
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·N SandersonS S Thorgeirsson
Nov 15, 1994·Biochemical and Biophysical Research Communications·T L YueG Feuerstein
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A B KulkarniS Karlsson
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·C SavageR W Padgett
Jun 5, 1998·The International Journal of Biochemistry & Cell Biology·D A Clark, R Coker
Jun 10, 1998·Cytokine & Growth Factor Reviews·C A Dinarello
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·M WeinsteinC X Deng
Jul 15, 2000·American Journal of Physiology. Renal Physiology·K A HruskaJ Morrissey
Apr 23, 2002·Kidney International·Frank StrutzEric G Neilson
Jul 3, 2002·Nature Reviews. Genetics·Brigid L M Hogan, Peter A Kolodziej
Dec 6, 2002·Endocrine Reviews·Hua ChangMartin M Matzuk
Jan 14, 2004·The Journal of Biological Chemistry·Ming Chang HuNorman D Rosenblum
Jan 31, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Michael Zeisberg, Raghu Kalluri
Feb 24, 2004·Infection and Immunity·Alexandra I MedeirosLúcia H Faccioli
Aug 18, 2005·Journal of Cell Science·Aristidis Moustakas, Carl-Henrik Heldin
Aug 27, 2005·Oncogene·Jiri Zavadil, Erwin P Böttinger
Dec 3, 2005·Genes & Development·Joan MassaguéDavid Wotton
Dec 22, 2005·American Journal of Physiology. Renal Physiology·Neil G DochertyR William G Watson
Jan 13, 2006·Kidney International·Youhua Liu
Feb 14, 2006·The American Journal of Clinical Nutrition·Charles A Dinarello
Jun 2, 2006·Proceedings of the American Thoracic Society·Brigham C WillisZea Borok
Sep 22, 2006·Kidney International·R L Chevalier

❮ Previous
Next ❯

Citations

Jan 4, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Lei HouLiying Li
Dec 19, 2020·Antioxidants·Erika Ramos-Tovar, Pablo Muriel
Mar 6, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Megan NguyenDevendra K Agrawal
Apr 29, 2021·Journal of Inflammation Research·Ting-Ting ChenWu-Yi Sun
Jun 18, 2021·Advanced Drug Delivery Reviews·Alexandros Marios SofiasTwan Lammers
Jul 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hung-Jen ShihChun-Jen Huang
Jul 25, 2021·International Journal of Molecular Sciences·Pengwei Li, Mingxian Chang
Aug 29, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shashi BalaGyongyi Szabo
Jan 11, 2022·Pharmacology Research & Perspectives·Keming HuangJian Feng
Nov 10, 2021·Annual Review of Pathology·Marcelle de Carvalho Ribeiro, Gyongyi Szabo

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase
nuclear translocation

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.