The role of nocturnin in early adipogenesis and modulation of systemic insulin resistance in human

Obesity
Siow-Wey HeeLee-Ming Chuang

Abstract

The deadenylase nocturnin (Noc, Ccrn4l) has been recently found to regulate lipid metabolism and to control preadipocyte differentiation. Here, we showed that among the five deadenylases tested, Noc and Pan2 exhibited a biphasic expression which is out of phase to each other during adipocyte differentiation of 3T3-L1 cells. The expression levels of other deadenylases, including Parn, Ccr4, and Caf1, were relatively unchanged or reduced. The immediate early expressed Noc during 3T3-L1 adipogenesis was involved in regulating mitotic clonal expansion (MCE) and cyclin D1 expression, as demonstrated in Noc-silenced 3T3-L1 cells and Noc(-/-) primary mouse embryonic fibroblasts (MEFs). Transcriptional profiling of Noc-depleted 3T3-L1 adipocytes revealed that most of the differentially expressed genes were related to cell growth and proliferation. In human adipose tissue, NOC mRNA level negatively associated with both fasting serum insulin and homeostasis model assessment of insulin resistance, and positively associated with both adiponectin mRNA levels and circulating adiponectin levels. Taken together, these results suggest the role of Noc in the modulation of early adipogenesis as well as systemic insulin sensitivity.

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Citations

Oct 14, 2014·International Journal of Molecular Sciences·Rüdiger Hardeland
Jul 5, 2016·International Journal of Molecular Sciences·Francisco Javier Ruiz-OjedaConcepción María Aguilera
Feb 26, 2019·Industrial Health·Alfredo Copertaro, Massimo Bracci
Oct 27, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ayelén M BlancoMaría J Delgado
Aug 31, 2019·BioMed Research International·Massimo BracciLory Santarelli
Sep 28, 2018·RNA Biology·Kelsey L HughesAaron C Goldstrohm
Dec 31, 2014·Molecular Cancer Research : MCR·Hélène BonIan G Mills

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