The role of Nogo-A in axonal plasticity, regrowth and repair

Cell and Tissue Research
Vincent Pernet, Martin E Schwab

Abstract

Axonal damage leads to permanent deficits in the adult central nervous system (CNS) not only because of the weak intrinsic ability of adult neurons to activate their growth program but importantly also because of the presence of specific growth inhibitors in the CNS tissue and the environment of the damaged axons. The well-studied myelin-derived protein Nogo-A is involved in various cellular and molecular events contributing to the failure of CNS axons to regrow and reconnect after transection. Recent studies have shown that, by acting in a negative way on the cytoskeleton and on the growth program of axotomized neurons, Nogo-A exerts fast and chronic inhibitory effects on neurite outgrowth. On the other hand, the blockade of Nogo-A results in a marked enhancement of compensatory and regenerative axonal extension in vivo; this enhancement is often paralleled by significant functional recovery, for example, of locomotion or skilled forelimb reaching after spinal cord or stroke lesions in rats and monkeys. Surprisingly, the blockade of Nogo-A or its receptor NgR in the hippocampus has recently been demonstrated to enhance long-term potentiation. A role of Nogo-A in synaptic plasticity/stability might therefore represent an additi...Continue Reading

References

Jul 21, 1998·The Journal of Biological Chemistry·A A SpillmannM E Schwab
Jun 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·O RaineteauM E Schwab
May 16, 2002·The Journal of Cell Biology·Yufang ShaoSimon Halegoua
Sep 25, 2002·Neurobiology of Disease·Luc DupuisJean-Philippe Loeffler
Apr 30, 2003·Neuron·Ji Eun KimStephen M Strittmatter
Apr 30, 2003·Neuron·Binhai ZhengMarc Tessier-Lavigne
Jul 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thomas OertleMartin E Schwab
Feb 18, 2004·Nature Neuroscience·Sha MiR Blake Pepinsky
Feb 18, 2004·Nature Neuroscience·Florence M BareyreMartin E Schwab
Jul 9, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jung-Kil LeeStephen M Strittmatter
Mar 24, 2005·Annals of Neurology·Natasa JokicVincent Meininger
Sep 21, 2005·Annals of Neurology·Thomas LiebscherMartin E Schwab
Oct 1, 2005·Science·Aaron W McGeeStephen M Strittmatter
May 26, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Leda DimouMartin E Schwab
Sep 8, 2006·Annals of Neurology·Xingxing WangStephen M Strittmatter
Oct 3, 2006·Molecular and Cellular Neurosciences·Benxiu JiJane K Relton
Nov 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William B J Cafferty, Stephen M Strittmatter
Dec 28, 2006·Apoptosis : an International Journal on Programmed Cell Death·Qingwen WanYingle Liu
Jul 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Onanong ChivatakarnRoman J Giger
Nov 3, 2007·Cellular and Molecular Life Sciences : CMLS·R R Gonzenbach, M E Schwab
Mar 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hakjoo LeeRoman J Giger
May 10, 2008·Stroke; a Journal of Cerebral Circulation·Joseph L CheatwoodGwendolyn L Kartje
Nov 8, 2008·Science·Jasvinder K AtwalMarc Tessier-Lavigne
Feb 12, 2009·The Journal of Biological Chemistry·Laura MontaniMartin E Schwab
Apr 24, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qi ShiRiqiang Yan
Jul 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qi ShiRiqiang Yan
Sep 19, 2009·Molecular Neurobiology·Michelle NashChristian Jacobson
Nov 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yvonne S YangStephen M Strittmatter
Dec 4, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philip DuffyStephen M Strittmatter
Jan 20, 2010·The Journal of Cell Biology·Armela JosetMartin E Schwab
Jan 21, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ertugrul KilicDirk M Hermann

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Citations

Jun 16, 2012·Cell and Tissue Research·H W MüllerM Bähr
May 4, 2013·Cell and Tissue Research·Petar CharalambousKlaus Unsicker
Nov 12, 2013·Neurobiology of Learning and Memory·Tomas PetrasekAles Stuchlik
May 28, 2014·Biochimica Et Biophysica Acta·Ali AlhoshaniMelanie J Cocco
Sep 28, 2014·Molecular and Cellular Neurosciences·Tristan G HeintzJames W Fawcett
Apr 14, 2015·Expert Review of Neurotherapeutics·Emma DevenneyMatthew C Kiernan
Jul 27, 2014·Expert Opinion on Drug Discovery·Barry W Festoff
Oct 17, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Hao ChenLi-Xia Xue
Dec 5, 2015·Journal of Molecular Neuroscience : MN·Jianglong YuAba Maier
Dec 30, 2015·Molecular and Cellular Neurosciences·Zhongqing SunFei Xiao
Dec 5, 2015·Frontiers in Cellular Neuroscience·Christoph EckharterRüdiger Schweigreiter
Apr 18, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Subhra Prakash HuiSukla Ghosh
Apr 24, 2013·The European Journal of Neuroscience·Yong Yu, Melitta Schachner
Jul 22, 2014·The European Journal of Neuroscience·Sandrine JolyVincent Pernet
Apr 30, 2014·Journal of Neurochemistry·Rolf HeumannMicaela Morelli
Apr 18, 2015·Neural Regeneration Research·Jian-Wei WangYa-Feng Zhang
May 24, 2014·Pharmacology & Therapeutics·Pericles CaliasPatricia Dickson
Aug 13, 2015·Neurochemical Research·Yun-Peng SuiFeng Sui
Mar 19, 2014·Current Opinion in Neurobiology·Martin E Schwab, Stephen M Strittmatter
Aug 6, 2013·The Biochemical Journal·Florian KernRüdiger Schweigreiter
Jul 9, 2013·Experimental Neurology·Lars Olson
Apr 4, 2015·Annual Review of Neuroscience·Hudson H FreezeMarc C Patterson
Dec 3, 2014·Neuropharmacology·Aline Barroso Spejo, Alexandre L R Oliveira
Apr 30, 2016·Experimental & Translational Stroke Medicine·Ahmed AlhusbanSusan C Fagan
Apr 30, 2016·Journal of Neuroinflammation·Bharath WootlaMoses Rodriguez

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