PMID: 7581305Jan 1, 1995Paper

The role of non-quantal release of acetylcholine in regulation of postsynaptic membrane electrogenesis

Journal of Physiology, Paris
F VyskocilJ Krůsek

Abstract

In mammalian nerve-muscle preparations treated with an anticholinesterase, the acetylcholine (ACh) released non-quantally (NQR) reaches the postsynaptic receptors and causes a small depolarization of the membrane potential at the endplate region of the muscle fibres. Increase in quantal release potentiates the NQR and vice versa, the amplitude and the kinetic parameters of quantal miniature endplate currents (MEPCs) change during manipulation of NQR, indicating direct interaction between both types of release. Repetitive binding of ACh to postsynaptic receptors which prolongs the time course of MEPCs in anti-cholinesterase-treated endplates leads within 1-2 h to progressive desensitization in the presence of non-quantal release and to the subsequent shortening of the quantal responses. We have also investigated the effect of procedures known to modulate non-quantal acetylcholine release, on the small, but obvious, difference in the resting membrane potential between the endplate zone and other areas of the mouse muscle fibre. The resting membrane potential at the endplate zone with intact cholinesterase is more negative (by 2-4 mV) than in the endplate-free area. The experiments were performed to test the hypothesis that the hy...Continue Reading

References

Feb 11, 1977·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B Katz, R Miledi
Sep 16, 1977·Pflügers Archiv : European journal of physiology·F Vyskocil, P Illés
Oct 19, 1977·Pflügers Archiv : European journal of physiology·F Vyskocil, E Gutmann
Mar 1, 1991·Pflügers Archiv : European journal of physiology·E E NikolskyF Vyskocil
Sep 11, 1989·Neuroscience Letters·H Zemková, F Vyskocil
Jan 1, 1988·Methods in Enzymology·J C Skou
Jan 1, 1986·International Review of Neurobiology·S Thesleff
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C EdwardsF Vyskocil
Jul 1, 1972·Physiological Reviews·R C Thomas
Jun 1, 1974·Acta Physiologica Scandinavica·S ThesleffM R Ward
Feb 28, 1969·Science·H Pinsker, E R Kandel
May 7, 1981·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B Katz, R Miledi
Jul 1, 1982·Physiological Reviews·L Tauc
Dec 1, 1982·The Journal of Physiology·R MilediR L Polak
Jan 1, 1982·The Journal of Physiology·S Tucek
Dec 1, 1993·The European Journal of Neuroscience·F Vyskocil, G Vrbová
Jun 28, 1954·The Journal of Physiology·J DEL CASTILLO, B KATZ
Jan 1, 1963·The Journal of Physiology·J F Mitchell, A Silver

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.