The Role of Noncoding RNA Pseudouridylation in Nuclear Gene Expression Events

Frontiers in Bioengineering and Biotechnology
Yang ZhaoJohn Karijolich

Abstract

Pseudouridine is the most abundant internal RNA modification in stable noncoding RNAs (ncRNAs). It can be catalyzed by both RNA-dependent and RNA-independent mechanisms. Pseudouridylation impacts both the biochemical and biophysical properties of RNAs and thus influences RNA-mediated cellular processes. The investigation of nuclear-ncRNA pseudouridylation has demonstrated that it is critical for the proper control of multiple stages of gene expression regulation. Here, we review how nuclear-ncRNA pseudouridylation contributes to transcriptional regulation and pre-mRNA splicing.

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Citations

Apr 6, 2019·Genome Biology and Evolution·Anna K M ÅsmanJohn M Archibald
Jun 15, 2018·Oncotarget·Oriol BachsMaria Jesús Pujol
Apr 18, 2020·Wiley Interdisciplinary Reviews. RNA·Phillip J McCownJessica A Brown
Sep 13, 2020·International Journal of Molecular Sciences·Crescenzio Francesco MinerviniFrancesco Albano
Jul 28, 2020·International Journal of Molecular Sciences·Katarzyna Taylor, Krzysztof Sobczak
Aug 20, 2020·Nucleic Acids Research·Yeek Teck GohW S Sho Goh
Apr 4, 2021·Cancers·Simon Jasinski-BergnerBarbara Seliger
Jul 3, 2021·International Journal of Molecular Sciences·Marek Kazimierczyk, Jan Wrzesinski

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Methods Mentioned

BETA
transglycosylation
immunoprecipitation
NMR

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