The Role of Notch Signaling and Leptin-Notch Crosstalk in Pancreatic Cancer

Medicines
Adriana HarbuzariuRuben R Gonzalez-Perez

Abstract

There is accumulating evidence that deregulated Notch signaling affects cancer development, and specifically pancreatic cancer (PC) progression. Notch canonical and non-canonical signaling has diverse impact on PC. Moreover, the actions of RBP-Jk (nuclear partner of activated Notch) independent of Notch signaling pathway seem to affect differently cancer progression. Recent data show that in PC and other cancer types the adipokine leptin can modulate Notch/RBP-Jk signaling, thereby, linking the pandemic obesity with cancer and chemoresistance. The potential pivotal role of leptin on PC, and its connection with Notch signaling and chemoresistance are still not completely understood. In this review, we will describe the most important aspects of Notch-RBP-Jk signaling in PC. Further, we will discuss on studies related to RBP-Jk-independent Notch and Notch-independent RPB-Jk signaling. We will also discuss on the novel crosstalk between leptin and Notch in PC and its implications in chemoresistance. The effects of leptin-Notch/RBP-Jk signaling on cancer cell proliferation, apoptosis, and drug resistance require more investigation. Data from these investigations could help to open unexplored ways to improve PC treatment success tha...Continue Reading

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Citations

May 31, 2020·International Journal of Molecular Sciences·Crystal C LipseyRuben R Gonzalez-Perez
Mar 17, 2019·Cellular Oncology (Dordrecht)·Ahmad GhasemiSeyed Isaac Hashemy
Oct 28, 2018·International Journal of Molecular Sciences·Priscilla CascettaCarmine Carbone
Aug 23, 2020·International Journal of Molecular Sciences·Antonio Pérez-PérezVíctor Sánchez-Margalet
May 12, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Fred E Bertrand

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Deltex

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