The role of Notch signaling in kidney podocytes

Clinical and Experimental Nephrology
Katsuhiko AsanumaEriko Tanaka

Abstract

The Notch signaling pathway is a basic cell-to-cell communication mechanism. This pathway is activated by the interaction between Notch receptors and the ligands of adjacent cells. Once activated, Notch receptors are cleaved and the intracellular domains translocate into the nucleus, where the transcription of target genes starts. In the mammalian kidney, Notch receptors are activated during nephrogenesis. Afterwards, in the mature glomeruli, the Notch pathway becomes silent. However, many researchers have reported the activation of Notch receptors in mature podocytes under pathological conditions. In this review, we discuss the role of Notch signaling in podocytes.

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Jun 1, 2019·Expert Opinion on Therapeutic Targets·Paola CassisGiuseppe Remuzzi
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Sep 12, 2018·The American Journal of Pathology·Ania ProchnickiChristoph Daniel

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