The role of NR2B containing NMDA receptor in place preference conditioned with morphine and natural reinforcers in rats

Experimental Neurology
Yao-Ying MaCai-Lian Cui

Abstract

It has been reported that N-methyl-D-aspartate (NMDA) receptor is implicated in drug addiction and antagonists of the NMDA receptor complex can inhibit the development and expression of conditioned place preference (CPP) induced by several addictive drugs, implying that this class of compounds might be considered as candidate for the treatment of substance abuse. To explore this possibility, it is important to evaluate whether the inhibitory effect of NMDA receptor antagonists would be confined to behaviors produced by drugs of abuse only, but not by natural reinforcers. According to the quantitative changes of NMDA receptor subunits, including NR1, NR2A, and NR2B, induced by diverse types of reinforcers, we chose NR2B subunit as the target of research. Experimental results showed that (1) an augmented expression of NR2B subunit was revealed by Western blotting in the nucleus accumbens (NAc) and the hippocampus in rats with CPP induced by morphine, but not by natural rewards such as food, novel environment and social interaction. (2) Ifenprodil, an antagonist highly selective for NR2B subunit of the NMDA receptor, produced a dose-dependent reduction in CPP induced by morphine and novel environment, but not that by food consumpt...Continue Reading

References

Dec 1, 1978·Journal of Consulting and Clinical Psychology·P B SutkerA N Allain
Jun 30, 1994·Behavioural Brain Research·H Dai, R J Carey
Jan 1, 1993·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·N K MelloJ H Mendelson
Oct 1, 1995·Neuropharmacology·H Mori, M Mishina
Nov 1, 1996·Comprehensive Psychiatry·J ScourfieldK R Merikangas
Apr 1, 1997·Current Opinion in Neurobiology·W Schultz
Oct 13, 1998·Neuron·G F KoobF E Bloom
Jul 23, 1999·Annals of the New York Academy of Sciences·B J EverittT W Robbins
Oct 8, 1999·Behavioural Brain Research·R A Bevins, M T Bardo
Oct 29, 2000·Trends in Neurosciences·S P OnnA A Grace
Oct 29, 2000·Trends in Neurosciences·P CalabresiG Bernardi
Mar 17, 2001·Nature Reviews. Neuroscience·E J Nestler
Sep 20, 2001·Current Medicinal Chemistry·B K Kohl, G Dannhardt
Nov 22, 2001·Hormones and Behavior·I Martínez, R G Paredes
Nov 15, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marius PappPaul Willner
Mar 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Piotr PopikBarbara S Slusher
May 13, 2003·Molecular Psychiatry·T M Tzschentke, W J Schmidt
Apr 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Joseph A KimHoward L Fields
Apr 14, 2004·The European Journal of Neuroscience·Emmanuel ValjentJocelyne Caboche
Jun 15, 2004·Neuroreport·On Ki Ma, Nikolaus J Sucher
Jun 16, 2004·Brain Research Bulletin·Arbi NazarianVanya Quinones-Jenab
Jul 15, 2004·Pharmacology, Biochemistry, and Behavior·Francisco CamachoRaúl G Paredes
Oct 16, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rita A FuchsRonald E See
Mar 3, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Guadalupe SoriaOlga Valverde

❮ Previous
Next ❯

Citations

Apr 3, 2007·European Archives of Psychiatry and Clinical Neuroscience·Juan J Canales
Dec 7, 2007·Cellular and Molecular Neurobiology·Albert C H YuJi-Sheng Han
Dec 21, 2011·BMC Neuroscience·Fouad Lemtiri-ChliehEric S Levine
Feb 19, 2011·BMC Neuroscience·Richard E MainsBetty A Eipper
Sep 2, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Drew D KiralyBetty A Eipper
Jan 10, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·George S PortugalJose A Morón
Jul 24, 2012·Neurobiology of Learning and Memory·Fang ShenCai-Lian Cui
Oct 26, 2011·Neuropharmacology·Xingjie PingCailian Cui
Sep 28, 2010·Biochemical and Biophysical Research Communications·Tobias JohanssonFred Nyberg
May 23, 2008·European Journal of Pharmacology·Carrie L WadeCarolyn A Fairbanks
Apr 29, 2008·Brain Research Reviews·Teresa Cunha-OliveiraCatarina R Oliveira
Oct 24, 2007·Peptides·Richard J Bodnar
Jul 18, 2009·Neuron·Yanhua H HuangYan Dong
May 11, 2010·Biological Psychiatry·Drew D KiralyBetty A Eipper
Mar 19, 2013·Experimental Neurology·Sarah A Woller, Michelle A Hook
Sep 26, 2015·Pharmacological Reviews·Esa R KorpiGavin S Dawe
Jul 31, 2013·Molecular Pharmacology·Drew D KiralyRichard E Mains

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Autoimmune Polyendocrinopathies

Autoimmune polyendocrinopathies, also called polyglandular autoimmune syndromes (PGASs), or polyendocrine autoimmune syndromes(PASs), are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. Discover the latest research on autoimmune polyendocrinopathies here.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.