The role of Nrf2 in autoimmunity and infectious disease: Therapeutic possibilities.

Advances in Pharmacology
Robert A Freeborn, Cheryl E Rockwell

Abstract

Nrf2 is a cytoprotective transcription factor which is involved in ameliorating oxidative stress and toxic insults. Recently, an immunomodulatory role for Nrf2 has gained appreciation as it has been shown to protect cells and hosts alike in a variety of immune and inflammatory disorders. However, Nrf2 utilizes numerous distinct pathways to elicit its immunomodulatory effects. In this review, we summarize the literature discussing the roles of Nrf2 in autoimmunity and infectious diseases with a goal of understanding the potential to therapeutically target Nrf2.

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Seminars in Cancer Biology
Jared SivinskiEli Chapman
OncoTargets and Therapy
Claudia GeismannHeiner Schäfer
Physiological Genomics
Qin M Chen, Anthony J Maltagliati
Oxidative Medicine and Cellular Longevity
Qinmei LiuXinxin Ci
© 2021 Meta ULC. All rights reserved