The role of NRG3 in mammary development.

Journal of Mammary Gland Biology and Neoplasia
Beatrice Howard

Abstract

The Neuregulin gene family encodes EGF-containing ligands which mediate their effects by binding to the ERBB receptor tyrosine kinases, a signalling network with important roles in both mammary gland development and breast cancer. Neuregulin3 (NRG3), a ligand for ERBB4, promotes early mammary morphogenesis and acts during specification of the mammary placode, an aggregate of epithelial cells that forms during mid-embryogenesis. Recent studies have shown that NRG3 can alter the cell fate of other epidermal progenitor populations when NRG3 is mis-expressed throughout the basal layer of the developing epidermis with the K14 promoter. Here evidence for a key function for NRG3 in promoting early mammary morphogenesis and the implication for the role of NRG3 in breast cancer and establishment of the mammary lineage are discussed.

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Citations

May 6, 2008·Journal of Mammary Gland Biology and Neoplasia·Maria SundvallKlaus Elenius
Jan 21, 2011·European Journal of Human Genetics : EJHG·Bregje W M van BonBert B A de Vries
Oct 24, 2009·Breast Cancer Research : BCR·Nancy E Hynes, Tina Stoelzle
May 17, 2012·PLoS Genetics·Clara Sze-Man TangMaria-Mercè Garcia-Barceló
Jul 19, 2014·Clinical Dysmorphology·Alice GardhamBirgitta Bernhard
May 31, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Dimitrios Avramopoulos

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