The role of nuclear factor erythroid 2-related factor 2 in hepatoprotective activity of natural products: A review

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Milad IranshahyGholamreza Karimi

Abstract

Internal metabolism and environmental toxicant exposure can be caused to generate reactive oxygen species in human organelles which lead to oxidative stress. The nuclear factor erythroid 2-related factor 2 (Nrf2), a basic leucine zipper (bZip) transcription factor, controls the expression of antioxidant response element (ARE)-dependent genes to regulate cellular resistance to oxidants. Nrf2 is an essential factor for hepatoprotection against drugs and xenobiotics. The key role of Nrf2 in hepatoprotection has been highlighted since Nrf2 knockout mice showed high sensitivity to xenobiotic-induced hepatotoxicity. Some natural products including polyphenols, terpenoids and alkaloids can induce Nrf2 expression as a key protein in the antioxidant defense system of hepatocytes. This review outlines natural product activators of Nrf2 that protect the liver from toxicity induced by xenobiotics.

Citations

Oct 20, 2018·BioFactors·Narges HedayatiGholamreza Karimi
Jun 6, 2019·Environmental Health Perspectives·Masahiro AkiyamaYoshito Kumagai
Feb 19, 2020·Phytotherapy Research : PTR·Kobra ShiraniGholamreza Karimi
Aug 25, 2020·Journal of Biochemical and Molecular Toxicology·Fatemeh YarmohammadiGholamreza Karimi
Dec 13, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Marbelis Francisco FernandezBorhane Annabi
Apr 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juan Rodrigo SalazarDiego Soto-Cabrera
Apr 12, 2020·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Jamshid TabeshpourGholamreza Karimi
Jul 26, 2019·International Journal of Molecular Sciences·Kemper Nunes Dos SantosM Fatima Leite
Sep 29, 2020·Phytotherapy Research : PTR·Fatemeh YarmohammadiGholamreza Karimi
Jan 19, 2019·International Journal of Molecular Sciences·Francesco PotìIlaria Zanotti
Jan 12, 2019·Cell Communication and Signaling : CCS·Hongming LvHaihua Feng
Aug 23, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gulcin TugcuAhmet Aydın
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luiz C Di Stasi
May 7, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Adriana CarinoStefano Fiorucci
Mar 13, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sameh M FaroukMahmoud A Emam
Feb 13, 2019·European Journal of Pharmacology·Milad IranshahyGholamreza Karimi
Apr 10, 2019·European Journal of Pharmacology·Elham SameiyanGholamreza Karimi
May 4, 2021·Veterinary World·Sahar M El-SheshtawyDalia H Samak
Sep 21, 2021·Phytotherapy Research : PTR·Seyyed Hossein HasheminezhadMilad Iranshahy

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