The role of oligodendrocytes and their progenitors on neural interface technology: A novel perspective on tissue regeneration and repair

Biomaterials
Steven M WellmanTakashi D Y Kozai

Abstract

Oligodendrocytes and their precursors are critical glial facilitators of neurophysiology, which is responsible for cognition and behavior. Devices that are used to interface with the brain allow for a more in-depth analysis of how neurons and these glia synergistically modulate brain activity. As projected by the BRAIN Initiative, technologies that acquire a high resolution and robust sampling of neural signals can provide a greater insight in both the healthy and diseased brain and support novel discoveries previously unobtainable with the current state of the art. However, a complex series of inflammatory events triggered during device insertion impede the potential applications of implanted biosensors. Characterizing the biological mechanisms responsible for the degradation of intracortical device performance will guide novel biomaterial and tissue regenerative approaches to rehabilitate the brain following injury. Glial subtypes which assist with neuronal survival and exchange of electrical signals, mainly oligodendrocytes, their precursors, and the insulating myelin membranes they produce, are sensitive to inflammation commonly induced from insults to the brain. This review explores essential physiological roles facilitate...Continue Reading

Citations

Nov 15, 2018·Micromachines·Takashi D Y Kozai
Apr 8, 2020·BioResearch Open Access·Walter H MoosXiaohong Chen
Feb 19, 2021·Nanoscale·Roberta FabbriValentina Benfenati
Feb 24, 2021·Journal of Neural Engineering·Mitchell DubaniewiczTakashi D Y Kozai
Apr 30, 2021·Frontiers in Cellular Neuroscience·Ouzéna Bouadi, Tuan Leng Tay
May 5, 2021·Developmental Neurobiology·Foluwasomi A OyefesoMichael J Pecaut

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