The role of Omega-3 and Omega-9 fatty acids for the treatment of neuropathic pain after neurotrauma

Biochimica Et Biophysica Acta. Biomembranes
Iriana Galán-ArrieroGerardo Ávila-Martín

Abstract

Omega-3 polyunsaturated fatty acids (PUFAs), such as docosaexaenoic acid (DHA) and eicosapentaenoic acid (EPA), mediate neuroactive effects in experimental models of traumatic peripheral nerve and spinal cord injury. Cellular mechanisms of PUFAs include reduced neuroinflammation and oxidative stress, enhanced neurotrophic support, and activation of cell survival pathways. Bioactive Omega-9 monounsaturated fatty acids, such as oleic acid (OA) and 2-hydroxy oleic acid (2-OHOA), also show therapeutic effects in neurotrauma models. These FAs reduces noxious hyperreflexia and pain-related anxiety behavior following peripheral nerve injury and improves sensorimotor function following spinal cord injury (SCI), including facilitation of descending inhibitory antinociception. The relative safe profile of neuroactive fatty acids (FAs) holds promise for the future clinical development of these molecules as analgesic agents. This article is part of a Special Issue entitled: Membrane Lipid Therapy: Drugs Targeting Biomembranes edited by Pablo V. Escribá.

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Citations

Oct 19, 2019·Metabolic Brain Disease·Meric A AltinozEmily Hacker
Aug 25, 2020·Journal of the Science of Food and Agriculture·Leontina LipanÁngel Carbonell-Barrachina
Dec 12, 2018·Nutritional Neuroscience·Hilal YildiranGizem Özata Uyar
May 9, 2019·Acta Cirúrgica Brasileira·Francisco Edson Ximenes Gomes PereiraKarine Saraiva da Silva
Jul 25, 2021·International Journal of Molecular Sciences·Marwa El SouryGiulia Ronchi
Aug 31, 2021·Frontiers in Pharmacology·Alessandro LeutiMauro Maccarrone

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