The Role of Oncolytic Viruses in the Treatment of Melanoma

Current Oncology Reports
Claire-Audrey Y BayanYvonne Saenger

Abstract

Oncolytic virotherapy is a new approach to the treatment of cancer and its success in the treatment of melanoma represents a breakthrough in cancer therapeutics. This paper provides a review of the current literature on the use of oncolytic viruses (OVs) in the treatment of melanoma. Talimogene laherparepvec (T-VEC) is the first OV approved for the treatment of melanoma and presents new challenges as it enters the clinical setting. Several other OVs are at various stages of clinical and pre-clinical development for the treatment of melanoma. Reports from phase Ib-III clinical trials combining T-VEC with checkpoint blockade are encouraging and demonstrate potential added benefit of combination immunotherapy. OVs have recently emerged as a standard treatment option for patients with advanced melanoma. Several OVs and therapeutic combinations are in development. Immunooncolytic virotherapy combined with immune checkpoint inhibitors is promising for the treatment of advanced melanoma.

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Citations

May 8, 2020·Melanoma Research·Claire Audrey-BayanYvonne M Saenger
Jan 16, 2020·Journal of Clinical Medicine·Masmudur M Rahman, Grant McFadden
Apr 9, 2020·Current Treatment Options in Oncology·Megan H TragerYvonne M Saenger
Jul 9, 2020·SAGE Open Medical Case Reports·Vladimirs SorokinsPēteris Alberts
Mar 31, 2019·Dermatology and Therapy·Dominika KwiatkowskaAdam Reich
Aug 14, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Dawn QueenNathalie C Zeitouni
May 8, 2021·Clinical & Experimental Metastasis·Dale HanDouglas Reintgen

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