The Role of Opioids and Their Receptors in Urological Malignancy: A Review

The Journal of Urology
Patrick M LecKarim Chamie

Abstract

We reviewed the literature surrounding the role of opioids and their receptors in urological malignancy. Recent studies have suggested clinically significant effects of agonism or antagonism of opioid receptors on cancer related outcomes and tumorigenesis. The focus of these efforts has centered on nonurological malignancies. However, a compelling body of evidence is growing in the fields of prostate, bladder and kidney cancer. A systematic review of English language articles published through 2020 was conducted with key phrases related to kidney, bladder or prostate cancer, and opioids or narcotics. A total of 837 unique records were identified, of which 49 were selected for full text review and 33 were included in the qualitative analysis. Eight records were identified via citation review and 1 study was recently presented at a national meeting. Retrospective reviews suggest poorer disease specific and recurrence-free survival with increased perioperative opioid administration in patients undergoing prostate or bladder cancer surgery. However, the data are controversial. Kappa opioid receptors are implicated in both proliferation and inhibition of prostate cancer cell growth across in vitro studies, with a proposed interactio...Continue Reading

Citations

Aug 4, 2021·Current Oncology Reports·Hao ZhangChanghong Miao
Oct 13, 2021·Pain Management·Maria F RamirezJuan P Cata
Dec 9, 2021·Molecular Medicine Reports·Qier ZhouNa Liang

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