The Role of Optineurin in Antiviral Type I Interferon Production

Frontiers in Immunology
Ahmed OutliouaDamien Arnoult

Abstract

After a viral infection and the stimulation of some pattern-recognition receptors as the toll-like receptor 3 in the endosomes or the RIG-I-like receptors in the cytosol, activation of the IKK-related kinase TBK1 leads to the production of type I interferons (IFNs) after phosphorylation of the transcription factors IRF3 and IRF7. Recent findings indicate an involvement of K63-linked polyubiquitination and of the Golgi-localized protein optineurin (OPTN) in the activation of this crucial kinase involved in innate antiviral immunity. This review summarizes the sensing of viruses and the signaling leading to type I IFN production following TBK1 activation through its ubiquitination and the sensing of ubiquitin chains by OPTN at the Golgi apparatus.

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Citations

Aug 6, 2019·Frontiers in Immunology·Morgan Brisse, Hinh Ly
May 18, 2021·Frontiers in Immunology·Raphaël JamiStéphane Biacchesi
Dec 10, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chandrashekhar D PatilDeepak Shukla

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Methods Mentioned

BETA
ubiquitination
transfection

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