PMID: 1208761Nov 21, 1975Paper

The role of orosensory stimuli from ethanol and blood-alcohol levels in producing conditioned taste aversion in the rat

Psychopharmacologia
M J Eckardt

Abstract

A taste-aversion paradigm was used to demonstrate that aversive consequences accompany the rapid oral ingestion of 5% (v/v) ethanol solutions. The learned taste aversion resulted from five 10-min self-administrations of alcohol mixed with an originally preferred flavor at a dosage of 1.69 g alcohol/kg body weight/day. In contrast, when the consumption of the alcohol solution was distributed throughout the day, a conditioned aversion was not obtained. This outcome was observed even though the distributed drinking animals were exposed to more orosensory stimuli and ingested more g/kg than the 10-min animals. The observation that those animals that drank their daily fluid in 10 min demonstrated higher peak blood-alcohol levels than the distributed animals supports the conclusion that a centrally mediated aversive state of inebriation must be present to produce a conditioned aversion.

References

Jun 1, 1974·Physiology & Behavior·R F Berman, D S Cannon

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Citations

May 31, 1978·Psychopharmacology·N Y WaltonJ Rogers
Jul 1, 1980·Pharmacology, Biochemistry, and Behavior·P J KulkoskyA L Riley
Sep 1, 1980·Pharmacology, Biochemistry, and Behavior·P J Kulkosky
Sep 1, 1987·Pharmacology, Biochemistry, and Behavior·D S Cannon, L E Carrell
Sep 1, 1987·Pharmacology, Biochemistry, and Behavior·D S Cannon, L E Carrell
Feb 1, 1993·Pharmacology, Biochemistry, and Behavior·H D DominguezJ C Molina
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·P J Kulkosky
Mar 27, 2001·Pharmacology, Biochemistry, and Behavior·K Ackroff, A Sclafani
Jun 1, 1991·Alcoholism, Clinical and Experimental Research·H L JuneM J Lewis
Aug 1, 1995·Alcoholism, Clinical and Experimental Research·P J KulkoskyL M Hopkins
Feb 3, 2000·Alcoholism, Clinical and Experimental Research·P AbateJ C Molina
Aug 16, 2001·Alcoholism, Clinical and Experimental Research·P AbateJ C Molina
Sep 15, 2007·Physiology & Behavior·Ricardo M PautassiNorman E Spear
Mar 28, 2007·Alcoholism, Clinical and Experimental Research·Eric M TruxellNorman E Spear
Feb 1, 1992·The Journal of Applied Bacteriology·T N Whitmore, S Denny

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