The role of osteogenic index, octahedral shear stress and dilatational stress in the ossification of a fracture callus

Medical Engineering & Physics
Trevor Noel GardnerLaurence Marks

Abstract

The exact mechanism by which mechanical stimulus regulates the healing process of a bone fracture is not understood. This has led to the development of several hypotheses that predict the pattern of differentiation of tissue during healing that may arise from characteristic fields of stress or strain at the fracture. These have so far remained unproved because data on stress fields in actual fracture tissue have been unavailable until recently. Thus the present study examines the predictive performance of the hypothesis proposed in J Orthop Res 6 (1988) 736, against measured and calculated data reported in J Biomech 33 (2000) 415, using a 2D FEM of a clinical fracture. The hypothesis was used to predict the influence of stress fields present in the Gardner et al. tissues at four temporal stages during healing. These predictions were then correlated with callus-size, rate of endochondral ossification and ossification pattern subsequently observed by Gardner et al. in the clinical fracture. Results corroborate the hypothesis that high octahedral shear stresses may increase the size of the callus during the initial phase of healing, and they also suggest that this may be true during the later stages of the fracture fixation period...Continue Reading

References

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Jun 6, 2003·Medical Engineering & Physics·Trevor Noel Gardner, Sanjay Mishra

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Citations

Jan 12, 2013·Biomechanics and Modeling in Mechanobiology·D ComiskeyJ O'Byrne
Jul 1, 2009·Integrative and Comparative Biology·Pui L Leong, Elise F Morgan
Dec 1, 2007·British Journal of Sports Medicine·P ZhangH Yokota
Aug 19, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ping ZhangHiroki Yokota
Jun 5, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Scott D RamsayJ Paul Santerre
Dec 7, 2005·Matrix Biology : Journal of the International Society for Matrix Biology·Elise F MorganDennis R Carter
Aug 9, 2017·Medical & Biological Engineering & Computing·Monan WangXinyu Wang

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