The role of oxidants and antioxidants in chronic tonsillitis and adenoid hypertrophy in children

International Journal of Pediatric Otorhinolaryngology
Taner YilmazH Tanju Besler

Abstract

To determine the possible role of oxidants and antioxidants in the pathogenesis of chronic tonsillitis (CT) and adenoid hypertrophy (AH) in children. Randomized, prospective, controlled. The study group was made up of children with chronic tonsillitis and adenoid hypertrophy who are to undergo tonsillectomy and adenoidectomy. The control group was constructed with otherwise healthy children with normal ENT examination. The blood levels of antioxidants (retinol, beta-carotene, alpha-tocopherol, laycopene, ascorbic acid, superoxide dismutase, glutathione peroxidase, GSH) and peroxidation products (malondialdehyde) were determined before and 1 month after the operation in the study group and once only in the control group. These antioxidants and peroxidation products were also measured in the tonsil and adenoid tissue that were obtained during operation. In the study group, the blood levels of antioxidants and oxidant before and after the operation were significantly different when compared to the control group (P < 0.05). In the study group, the blood antioxidant levels increased and oxidant level decreased significantly after the operation (P < 0.05). These levels after the operation never reached those of the control group. Oxi...Continue Reading

References

Feb 1, 1997·Archives of Otolaryngology--head & Neck Surgery·G J WesterveldR A Scheeren

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Citations

Jun 18, 2005·International Journal of Pediatric Otorhinolaryngology·A Faruk KirogluTolga Kara
Dec 4, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Taner YilmazBülent Gürsel
Feb 2, 2013·Journal of Clinical and Diagnostic Research : JCDR·Jayshree Shriram Dawane, Vijaya Anil Pandit
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Feb 6, 2016·Biological Trace Element Research·Małgorzata Michalska-MosiejMaria Halina Borawska
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Apr 13, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T IannittiB Palmieri
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