The role of oxidative stress as a risk factor for rupture of posterior inferior cerebellar artery aneurysms

Molecular Biology Reports
V ŠćepanovićLj Šćepanović

Abstract

Cerebral aneurysm affects 2-5% of the population and posterior inferior cerebellar artery (PICA) aneurysms account for 1-3% of all intracranial aneurysms. Oxidative stress is known to contribute to the progression of cerebrovascular disease and it may be increased by inflammation, a key contributor to cerebral aneurysm development and rupture. The aim of this study was to examine the role of overall oxidative stress as a risk factor for rupture of PICA aneurysms. This study included 29 patients with PICA aneurysms: 18 ruptured and 11 unruptured. We determined catalase, malondialdehyde, myeloperoxidase and carbonyl groups in homogenates of excised aneurysm tissue after surgery and plasma levels of C reactive protein and fibrinogen. The patient's age and sex, size of aneurysms, multiplicity, history of previous subarachnoidal hemorrhage (SAH) and risk factors for oxidative stress such as hypertension and smoking were compared between unruptured and ruptured aneurysms. Maximal diameter and SAH history were independent predictors for aneurysm rupture. Activity of catalase was decreased while activity of myeloperoxidase, levels of malondialdehyde, carbonyl groups in aneurismal tissue and plasma levels of C reactive protein and fibri...Continue Reading

References

Oct 1, 1992·Stroke; a Journal of Cerebral Circulation·D O WiebersI Meissner
Jan 1, 1990·Methods in Enzymology·R L LevineE R Stadtman
Jul 15, 1983·Analytical Biochemistry·K SuzukiT Fujikura
Dec 15, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·H A CynamonC H Nguyen
Jan 1, 1984·Methods in Enzymology·H Aebi
Jan 1, 1993·British Journal of Neurosurgery·J RosenłrnK Schmidt
Dec 20, 2002·Nature·Peter Libby
Jun 28, 2003·Stroke; a Journal of Cerebral Circulation·Seppo Juvela
Jul 18, 2003·Lancet·David O WiebersUNKNOWN International Study of Unruptured Intracranial Aneurysms Investigators
Aug 21, 2003·JAMA : the Journal of the American Medical Association·Daniel G Hackam, Sonia S Anand
Jan 30, 2007·Lancet·Jan van GijnGabriel J E Rinkel
Feb 13, 2007·Trends in Cardiovascular Medicine·Christopher A Papaharalambus, Kathy K Griendling
Mar 3, 2007·Stroke; a Journal of Cerebral Circulation·Marieke J H WermerGabriël J E Rinkel
Jun 16, 2007·Stroke; a Journal of Cerebral Circulation·Axel J RosengartR Loch Macdonald
Apr 22, 2009·Blood·Marianne Jensby Nielsen, Søren Kragh Moestrup
Oct 8, 2011·Stroke; a Journal of Cerebral Circulation·Koji Sato, Yuhei Yoshimoto
Jan 18, 2012·Acta Neuropathologica·Juhana FrösenJuha Hernesniemi
Jun 29, 2012·The New England Journal of Medicine·Akio MoritaTakashi Yoshimoto
Jan 29, 2013·Journal of Neurosurgery·Nohra ChalouhiAaron S Dumont
May 30, 2013·Current Neurovascular Research·Robert M StarkeAaron S Dumont
Aug 21, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Ioannis ParastatidisW Robert Taylor
Oct 15, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·David L PennE Sander Connolly
Apr 10, 2014·Stroke; a Journal of Cerebral Circulation·Matthew J GounisAlexei A Bogdanov
Oct 30, 2015·Neurology·Tomohito HishikawaUNKNOWN For UCAS Japan and UCAS II Investigators
Oct 28, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Wei-Wei LuYong-Fen Qi
Jan 27, 2017·Translational Neuroscience·Ruo-Shi ZangHua-Gang Li
May 10, 2017·Journal of Vascular Surgery·Gözde TekinAdnan Çobanoğlu
Jun 28, 2017·The Journal of Thoracic and Cardiovascular Surgery·Marie BillaudThomas G Gleason

❮ Previous
Next ❯

Citations

Dec 8, 2020·World Neurosurgery·Vedat AcikAli İhsan Ökten

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA

Software Mentioned

SPSS Statistics
SPSS

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.