The Role of Oxidative Stress in Common Risk Factors and Mechanisms of Cardio-Cerebrovascular Ischemia and Depression

Oxidative Medicine and Cellular Longevity
Danfeng LinAnwen Shao

Abstract

The public health sector faces a huge challenge as a result of the high prevalence and burden of disability caused by ischemic cardio-cerebrovascular disease (CVD) and depression. Although studies have explored the underlying mechanisms and potential therapies to address conditions, there is no treatment breakthrough, especially for depression which is highly influenced by social stressors. However, accumulating evidence reveals that CVD and depression are correlated and share common risk factors, particularly obesity, diabetes, and hypertension. They also share common mechanisms, including oxidative stress (OS), inflammation and immune response, cell death signaling pathway, and microbiome-gut-brain axis. This review summarizes the relationship between ischemic CVD and depression and describes the interactions among common risk factors and mechanisms for these two diseases. In addition, we propose that OS mediates the crosstalk between these diseases. We also reveal the potential of antioxidants to ameliorate OS-related injuries.

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Citations

Oct 17, 2020·Experimental Neurology·Eunhee Kim, Sunghee Cho
Mar 30, 2021·Oxidative Medicine and Cellular Longevity·Jinnan DuanJifang Sheng
Apr 27, 2021·Oxidative Medicine and Cellular Longevity·Mateusz MaciejczykKarolina Gerreth
Jul 15, 2021·Oxidative Medicine and Cellular Longevity·Du XiangYanfeng Wang

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