The role of oxidative stress in female infertility and in vitro fertilization

Postȩpy higieny i medycyny doświadczalnej
Joanna WojsiatHalina Małgorzata Żbikowska

Abstract

Infertility problem involves many couples of reproductive age. It has been estimated that in Poland 0.7-1.0 million pairs require treatment, while for more than half of them assisted reproduction is the only recommended and effective method. Infertility affects 13 to 15% of the world's population. A major concern is the age-related decline in female fertility even more that often a decision about pregnancy is taken at later age. Recent studies show that increased production of reactive oxygen species is an important factor in etiopathogenesis of pregnancy and affects female reproduction. It was found that oxidative stress may damage the oocytes and may impair their fertilization capacity. Oxidative stress may also lead to embryo fragmentation and formation of numerous developmental abnormalities, and is regarded to be one of the important reasons of spontaneous and recurrent miscarriage. Moreover, overproduction of reactive oxygen species has a significant impact on the success of in vitro fertilization (IVF).

Citations

Dec 22, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Irina Vladimirovna DankovaRukosuev Nikita Evgenyevich
Aug 22, 2018·Reproductive Biology and Endocrinology : RB&E·Jiayin LuYulan Dong
Jul 11, 2019·Current Molecular Medicine·Jing WangHua Yan
Jul 16, 2020·Antioxidants·Maria Cristina Budani, Gian Mario Tiboni
Aug 23, 2019·Animal Biotechnology·Roberto R da Rosa FilhoCristina F Lucio
Mar 7, 2021·Journal of Clinical Medicine·Maja PešićAna Čipak Gašparović
May 1, 2021·Antioxidants·Beatriz Moreira-PintoIrene Rebelo
Oct 12, 2021·Systems Biology in Reproductive Medicine·Mark JainOlga Panina

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