journal cover

The role of oxidative stress in organophosphate and nerve agent toxicity

Annals of the New York Academy of Sciences

Aug 1, 2016

Jennifer N Pearson, Manisha Patel

Get paper from

Abstract

Organophosphate (OP) nerve agents exert their toxicity through inhibition of acetylcholinesterase. The excessive stimulation of cholinergic receptors rapidly causes neuronal damage, seizures, death, and long-term neurological impairment in those that survive. Owing to the lethality of o...read more

Mentioned in this Paper

Oxidative Stress
Toxic Encephalitis
Study
DNA Damage
Brain Damage, Chronic
Cholinesterase Inhibitors, Reversible
Oxidative Stress Analysis
Metazoa
Metabolic Inhibition
Mitochondrial Inheritance
Paper Details
References
  • References56
  • Citations5
12345...

Similar Papers Found In These Feeds

Organophosphorus Counteractive Agents

Organophosphorus compounds are organic compounds used in medications, insecticides, and nerve agents. Exposure to these compounds and their derivatives is associated with several health conditions including increased cancer risk. Here is the latest research on agents that can counteract organophosphorus compounds.

Neurotoxicity, Inflammation & Neuroprotection

The end result of the inflammatory process, neurotoxicity and/or neuroprotection, is a function of the fine balance between the two cellular systems, i.e., of the complex signaling relationships between anti-inflammatory neuroprotective factors (neurotrophins and other chemical mediators) and proinflammatory neurotoxic factors (tnf, free radicals, certain cytokines, etc). Here are the latest discoveries pertaining to neurotoxicity, inflammation and neuroprotection.

ROS & Mitochondria

Reactive oxygen species can be generated during mitochondrial processes including oxidative phosphorylation and can contribute to DNA damage. Here is the latest research on ROS and mitochondria.

© 2019 Meta ULC. All rights reserved

The role of oxidative stress in organophosphate and nerve agent toxicity

Annals of the New York Academy of Sciences

Aug 1, 2016

Jennifer N Pearson, Manisha Patel

PMID: 27371936

DOI: 10.1111/nyas.13115

Abstract

Organophosphate (OP) nerve agents exert their toxicity through inhibition of acetylcholinesterase. The excessive stimulation of cholinergic receptors rapidly causes neuronal damage, seizures, death, and long-term neurological impairment in those that survive. Owing to the lethality of o...read more

Mentioned in this Paper

Oxidative Stress
Toxic Encephalitis
Study
DNA Damage
Brain Damage, Chronic

Related Papers

Paper Details
References
  • References56
  • Citations5
12345...

Get paper from

/papers/the-role-of-oxidative-stress-in-organophosphate/27371936