The role of oxygen-derived free radicals in ischemia-induced increases in canine skeletal muscle vascular permeability

Circulation Research
R J KorthuisA E Taylor


Previous studies indicate that vascular permeability is increased in skeletal muscle subjected to 4 hours of inflow occlusion. However, the mechanism(s) underlying the increase in permeability are unknown. The aim of this study was to assess the role of oxygen-derived free radicals and histamine as putative mediators of the increased permeability in skeletal muscle subjected to 4 hours of inflow occlusion. The osmotic reflection coefficient for total plasma proteins and isogravimetric capillary pressure were estimated in canine gracilis muscle for the following conditions: control, ischemia, and ischemia plus pretreatment with allopurinol (a xanthine oxidase inhibitor), catalase (a peroxidase that reduces hydrogen peroxide to water and molecular oxygen), superoxide dismutase (a superoxide anion scavenger), dimethyl sulfoxide (a hydroxyl radical scavenger), diphenhydramine (a histamine H1-receptor blocker), or cimetidine (a histamine H2-receptor blocker). Ischemia, followed by reperfusion, significantly reduced the reflection coefficient from 0.94 +/- 0.02 to 0.64 +/- 0.02 and isogravimetric capillary pressure from 13.8 +/- 1.0 mm Hg to 6.9 +/- 0.4 mmHg, indicating a dramatic increase in microvascular permeability. Prior treatme...Continue Reading


Jul 1, 1975·The American Journal of Physiology·J E McNamee, F S Grodins
Sep 1, 1978·The Histochemical Journal·B Ibrahim, P J Stoward
Nov 1, 1975·Clinical Orthopaedics and Related Research·R A SandersonW H Kirkaldy-Willis
Jul 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·G L MillerG J Grega
Feb 1, 1985·Journal of Applied Physiology·B RippeA E Taylor
Sep 1, 1971·American Heart Journal·R A DeWallP Kezdi
Jun 1, 1968·The American Journal of Physiology·C E JonesE E Smith
Apr 1, 1969·The American Journal of Physiology·J W CrowellE E Smith
Feb 1, 1980·Neurologia Medico-chirurgica·Y FujitaT Kawano
Nov 1, 1982·Canadian Journal of Physiology and Pharmacology·M L HessE Okabe
Mar 21, 1983·Life Sciences·G L Tritsch, P W Niswander
Jun 1, 1984·The American Journal of Physiology·K P BurtonG Ghai
Oct 1, 1984·The Journal of Clinical Investigation·M S PallerT F Ferris
Jan 1, 1982·The American Journal of Anatomy·R B ArmstrongC R Taylor
Nov 1, 1984·Microvascular Research·R J KorthuisW S Spielman
Oct 1, 1965·The Biochemical Journal·U A Al-Khalidi, T H Chaglassian

❮ Previous
Next ❯


Mar 29, 2002·Biomedical Chromatography : BMC·P MaboudouM Lhermitte
Jan 1, 1990·Archives of Orthopaedic and Trauma Surgery·B GrøgaardO Reikerås
Jan 1, 1988·Acta Neuropathologica·A UnterbergA Baethmann
Jan 1, 1993·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·S SkjeldalO Reikerås
Jan 1, 1994·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·O BüyükgebizZ S Ercan
Jul 20, 2007·Archives of Orthopaedic and Trauma Surgery·Fuat DuyguluAhmet Ozturk
Oct 26, 2010·European Journal of Applied Physiology·Takanobu OkamotoKomei Ikuta
Nov 3, 2006·Inflammation·Edward C T H TanR Jan A Goris
Nov 20, 1992·Regulatory Peptides·C FagnyM Deschodt-Lanckman
Feb 1, 1989·Journal of the American College of Cardiology·D R Hathaway, K L March
Jan 1, 1988·Free Radical Biology & Medicine·J M McCord
Jan 1, 1988·Free Radical Biology & Medicine·G M Rubanyi
Jan 1, 1990·Free Radical Biology & Medicine·M G Steiner, C F Babbs
Jan 1, 1990·Free Radical Biology & Medicine·K Asayama, K Kato
Jan 1, 1996·Free Radical Biology & Medicine·H GaoJ N Benoit
Jun 1, 1996·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·M GennaroE Ascer
May 1, 1994·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·R CirilloM Prosdocimi
Mar 1, 1995·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S BertugliaA Colantuoni
Sep 15, 1998·The American Journal of Pathology·C R KieferL M Snyder
Jul 10, 2003·The Journal of Surgical Research·Cengiz KoksalAyla Gurel Sayin
Jan 1, 1997·Free Radical Biology & Medicine·L A Bharadwaj, K Prasad
May 1, 1994·European Journal of Vascular Surgery·S OredssonP Qvarfordt
Apr 1, 1989·European Journal of Vascular Surgery·P NeglénB Eklöf
Nov 28, 2002·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·F William Blaisdell
Sep 2, 1998·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·D JohnsonJ B Towne
Jul 1, 1995·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·T Ali ZirhF Onat
Jun 19, 1998·Journal of the American College of Surgeons·M S Slater, R J Mullins
Mar 1, 1997·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L M WaagsteinH Haljamäe
Dec 12, 2001·Acta Physiologica Scandinavica·H A MachielsP N Dekhuijzen
Feb 13, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Rainer MittermayrHeinz Redl

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.