The role of oxysterol binding protein-related protein 5 in pancreatic cancer

Cancer Science
Shinji IshikawaHideo Baba

Abstract

The expression of oxysterol binding protein-related protein (ORP) 5 is related to invasion and a poor prognosis in pancreatic cancer patients. ORP5 induced the expression of sterol response element binding protein (SREBP) 2 and activated the downstream gene of sterol response element. ChIP using SREBP2 antibody revealed that histone deacetylase 5 (HDAC5) was one of the downstream genes of SREBP2. The effect of HMG-CoA reductase inhibitors (statins) were analyzed according to the expression level of ORP5. The invasion rate and growth was suppressed in cells that strongly expressed ORP5 in a time- and dose-dependent manner, but had less effect in cells weakly expressing ORP5, suggesting that when the potential of invasion and growth relies on the cholesterol synthesis pathway, it becomes sensitive to HMG-CoA reductase inhibitor. Furthermore, HDAC inhibitor, tricostatin A, induced the expression of phosphatase and tensin homolog as well when ORP5 was suppressed or the cells were treated with statin. Treatment with both statin and tricostatin A showed a synergistic antitumor effect in cells that highly expressed ORP5. Therefore, in some pancreatic cancers, continuous ORP5 expression enhances the cholesterol synthesis pathway and th...Continue Reading

References

Oct 25, 1996·The Journal of Biological Chemistry·R SatoM Maeda
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·A TanP B Bitterman
Dec 9, 2000·Biochimica Et Biophysica Acta·K SchoonjansJ Auwerx
Dec 12, 2001·Genomics·C J JaworskiI R Rodriguez
Aug 12, 2005·Molecular Cancer Therapeutics·Pilar García-MoralesMiguel Saceda
Mar 22, 2006·Molecular Carcinogenesis·Watcharin LoilomeMasanao Miwa
Feb 17, 2007·Current Opinion in Cell Biology·Maria T Bengoechea-Alonso, Johan Ericsson
Jun 9, 2007·Biochimica Et Biophysica Acta·Massimo DonadelliMarta Palmieri
Oct 26, 2007·Journal of Cellular Biochemistry·Melinda M MortensonRichard J Bold
Nov 17, 2007·Cancer·Gaia PocobelliKathleen M Egan
Dec 11, 2007·Human Molecular Genetics·Rosemary E TeresiCharis Eng
Feb 23, 2008·Trends in Endocrinology and Metabolism : TEM·Rajendra RaghowMarshall B Elam
Aug 19, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jaana KuoppalaEero Pukkala

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Citations

Jul 6, 2012·Surgery·John R HornickWilliam G Hawkins
Mar 26, 2011·Journal of Cellular and Molecular Medicine·Andrea ClocchiattiClaudio Brancolini
Sep 12, 2012·Molecular Oncology·Bruna Barneda-Zahonero, Maribel Parra
Aug 20, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiromitsu HayashiHideo Baba
Feb 23, 2018·Experimental Biology and Medicine·Lei ZhengXiu-An Yang
Sep 24, 2016·Clinical Science·Ugo Soffientini, Annette Graham
Aug 28, 2020·European Journal of Clinical Investigation·Nooshin MohammadzadehAmirhossein Sahebkar
Apr 30, 2017·Oncology Letters·Jun GongMonica M Mita
Aug 28, 2019·Life Science Alliance·Walaa E KattanJohn F Hancock
Mar 15, 2018·Cellular and Molecular Life Sciences : CMLS·Antonietta Pietrangelo, Neale D Ridgway
Aug 6, 2019·Frontiers in Endocrinology·Urša KovačTadeja Režen
Aug 17, 2020·The Biochemical Journal·Walaa E Kattan, John F Hancock
Jun 24, 2020·Biomolecules·Nina Criado SantosPaula Nunes-Hasler
Feb 23, 2021·Frontiers in Cell and Developmental Biology·Chenlu LiHaijia Yu

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