The role of oxytocin in alcohol and drug abuse.

Brain Research
Courtney E KingHoward C Becker

Abstract

The neuropeptide oxytocin (OXT) plays a key role in adaptive processes associated with reward, tolerance, memory and stress responses. Through interactions with brain reward and stress systems, OXT is known to play a role in several neuropsychiatric disorders, particularly those that involve altered social integration, such as alcohol and drug addiction (Heilig et al., 2016). As such, there is growing interest in the oxytocin system as a potential therapeutic target for the treatment of alcohol and substance use disorders. Accumulating preclinical evidence suggests that administration of OXT influences the development of tolerance, sensitization and withdrawal symptoms, and modulates numerous alcohol/drug-seeking and alcohol/drug-taking behaviors. Further, there is some evidence to suggest that OXT may help to reverse neuroadaptations that occur as a result of chronic alcohol or drug exposure. To date, there have been only a handful of clinical studies conducted in alcohol and drug dependent populations. This review summarizes the preclinical and clinical literature on the effects of OXT administration on alcohol- and drug-related behaviors. In addition, we discuss OXT interactions with the hypothalamic-pituitaryadrenal axis an...Continue Reading

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Citations

Nov 20, 2020·The International Journal of Neuropsychopharmacology·Thang M LeChiang-Shan R Li
Dec 23, 2020·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Katrine MelbyOlav Spigset
Oct 19, 2020·Hormones and Behavior·M D ReguilónM Rodríguez-Arias
Mar 7, 2021·International Journal of Molecular Sciences·Carmen Ferrer-PérezMarta Rodríguez-Arias
Jun 9, 2020·Pharmacology & Therapeutics·Samata R SharmaFrank I Tarazi
Apr 2, 2021·Neuropharmacology·Santiago BallazMichel Bourin
Apr 13, 2021·Current Opinion in Pharmacology·Fabrizio Sanna, Maria Antonietta De Luca
Apr 6, 2021·British Journal of Pharmacology·Mariana RaeLakshmi A Devi
Jun 3, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Bernd LenzChristiane Mühle
Jun 9, 2021·Neuroscience and Biobehavioral Reviews·Andrey E Ryabinin, Hannah D Fulenwider
Jun 16, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Courtney E KingHoward C Becker
Aug 28, 2021·International Journal of Molecular Sciences·Mohammad Saied SalehiSareh Pandamooz
Jul 9, 2021·British Journal of Pharmacology·Ben HoughtonAlexis Bailey

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