The role of oxytocin in modulating self-other distinction brain: a pharmacological fMRI study

BioRxiv : the Preprint Server for Biology
Y. WangHaiyan Wu

Abstract

The self-other distinction is crucial in human social cognition and social interaction. Studies have found that oxytocin (OT) sharpens the self-other perceptual boundary but with mixed results. Further, little is known if the effect of OT on self-resemblance face perception exists, especially on its neural basis. Moreover, it is unclear if OT would influence the judgment in self-other discrimination when the other is a child or an adult. In the current double-blinded, placebo-controlled study, we investigated the effect of OT on self-face perception at both behavioral and neural levels. We morphed their faces with either an adult, a child, or a stranger face of either an adult or child. After being treated by either OT or placebo (PL), participants reported whether a morphed face resembles themselves while being scanned with fMRI. Behavioral results showed that people judged adult-morphed faces better than child-morphed faces. fMRI results showed that the OT group exhibited generally increased activities in the visual area and IFG for self-morphed faces. Such difference was more pronounced in the adult face compared to child face conditions. Multivariate fMRI analysis revealed that the OT group showed better classification betw...Continue Reading

Methods Mentioned

BETA
RSA
PCA

Software Mentioned

Neurosynth
MVPA
sklearn
AAL3
Abrosoft Fanta Morph
R
sklearn package
Decoding Toolbox ( TDT )
Statistical Parametric Mapping
Adobe Photoshop CS

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