The role of oxytocin receptor gene (OXTR) DNA methylation (DNAm) in human social and emotional functioning: a systematic narrative review

BMC Psychiatry
Catherine MaudCraig A Olsson

Abstract

The neuropeptide Oxytocin (OXT) plays a central role in birthing, mother-infant bonding and a broad range of related social behaviours in mammals. More recently, interest has extended to epigenetic programming of genes involved in oxytocinergic neurotransmission. This review brings together early findings in a rapidly developing field of research, examining relationships between DNA methylation (DNAm) of the Oxytocin Receptor Gene (OXTR) and social and emotional behaviour in human populations. A systematic search across Web of Knowledge/Science, Scopus, Medline and EMBASE captured all published studies prior to June 2017 examining the association between OXTR DNAm and human social and emotional outcomes. Search terms included 'oxytocin gene' or 'oxytocin receptor gene' and 'epigenetics' or 'DNA methylation'. Any article with a focus on social and emotional functioning was then identified from this set by manual review. Nineteen studies met eligibility criteria. There was considerable heterogeneity of study populations, tissue samples, instrumentation, measurement, and OXTR site foci. Only three studies examined functional consequences of OXTR DNAm on gene expression and protein synthesis. Increases in OXTR DNAm were associated ...Continue Reading

References

Apr 9, 1992·Nature·T KimuraH Okayama
Feb 1, 1990·Nutrition Reviews·K Uvnäs-Moberg
Mar 29, 2001·Physiological Reviews·G Gimpl, F Fahrenholz
Oct 16, 2001·The Journal of Clinical Endocrinology and Metabolism·M HeinrichsD H Hellhammer
Dec 1, 2001·Biochemical and Biophysical Research Communications·C KusuiY Murata
Jul 9, 2004·Pediatric Research·Peter D Gluckman, Mark A Hanson
Jun 3, 2005·Nature·Michael KosfeldErnst Fehr
Aug 15, 2006·Biological Psychiatry·Eric HollanderStacey Wasserman
May 25, 2007·Nature·Adrian Bird
Jul 10, 2007·Biological Psychiatry·Gregor DomesSabine C Herpertz
Sep 6, 2008·Journal of Child Psychology and Psychiatry, and Allied Disciplines·James E SwainJames F Leckman
Nov 14, 2008·Psychosomatic Medicine·Jill M CyranowskiJanet A Amico
Nov 19, 2008·Social Cognitive and Affective Neuroscience·Marian J Bakermans-Kranenburg, Marinus H van Ijzendoorn
Jan 14, 2009·American Journal of Epidemiology·Debra L FoleyRichard Saffery
May 22, 2009·Psychoneuroendocrinology·Anna BuchheimHarald Gündel
Aug 28, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lane StrathearnP Read Montague
Nov 10, 2009·Biological Psychiatry·Adam J GuastellaIan B Hickie
Nov 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sarina M RodriguesDacher Keltner
Apr 3, 2010·Biological Psychiatry·Ilanit GordonRuth Feldman
Aug 7, 2010·Psychoneuroendocrinology·Benjamin A TabakPhilip M McCabe
Jan 7, 2011·Psychoneuroendocrinology·Daniella J FurmanIan H Gotlib
Aug 20, 2011·Nature Reviews. Neuroscience·Andreas Meyer-LindenbergMarkus Heinrichs
Sep 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Shimon Saphire-BernsteinShelley E Taylor
Feb 18, 2012·Biological Psychiatry·Ruth FeldmanRichard P Ebstein
Apr 18, 2012·International Journal of Epidemiology·Andy BoydGeorge Davey Smith
Sep 15, 2012·Trends in Neurosciences·Inga D Neumann, Rainer Landgraf
Mar 30, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Robert LoweSreeram V Ramagopalan
Sep 26, 2013·Development and Psychopathology·Mark R DaddsRichard E Ebstein
Sep 26, 2013·Development and Psychopathology·Mark R DaddsRichard E Ebstein
Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·David H SkuseLarry J Young
Jan 8, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christiane ZieglerKatharina Domschke
Feb 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Meghan H PugliaJessica J Connelly

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Citations

Dec 12, 2019·European Eating Disorders Review : the Journal of the Eating Disorders Association·Lea ThalerHoward Steiger
Oct 18, 2019·Genes, Brain, and Behavior·Livio ProvenziRenato Borgatti
Aug 20, 2020·Epigenomics·Denis Pereira GrayPhilip Dean
Jan 31, 2020·Frontiers in Psychiatry·Amaia M Erdozain, Olga Peñagarikano
Sep 29, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Nina MarshRené Hurlemann
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Qiuyue XuBin Yuan
Oct 8, 2020·Harvard Review of Psychiatry·Catarina Raposo-Lima, Pedro Morgado
Nov 5, 2020·Autism : the International Journal of Research and Practice·Amy Niego, Antonio Benítez-Burraco
Dec 12, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Maria YarmolinskayaNatalia Tkachenko
Jan 5, 2021·Journal of Autism and Developmental Disorders·Michelle T SiuRosanna Weksberg
Nov 30, 2018·Neuroscience and Biobehavioral Reviews·Eline J KraaijenvangerMarco P M Boks
Feb 23, 2020·Neuroscience and Biobehavioral Reviews·Charlotte A M CecilTobias Nolte
Sep 27, 2020·Hormones and Behavior·Desirée De LeonMar M Sanchez
Jan 29, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Eda SünnetçiOytun Erbaş
Feb 6, 2021·Translational Psychiatry·Ariane WiegandVanessa Nieratschker
Feb 9, 2021·Reviews in the Neurosciences·Olga L LopatinaAlla B Salmina
Feb 8, 2021·Neuroscience and Biobehavioral Reviews·Terence Y PangRupshi Mitra
Feb 15, 2021·Psychoneuroendocrinology·Corinne D WarrenerJames K Rilling
Mar 18, 2021·Neuroscience and Biobehavioral Reviews·Francesco CraigRosario Montirosso
May 4, 2021·Reviews in the Neurosciences·Annamaria SrancikovaJan Bakos
Jun 3, 2021·International Journal of Molecular Sciences·Niki MourtziEvangelia Charmandari
Jun 29, 2021·Frontiers in Cell and Developmental Biology·Talita BaptistaRodrigo Grassi-Oliveira
Aug 24, 2021·The Nucleus : an International Journal of Cytology and Allied Topics·Gaurab Aditya DharRonita Nag Chaudhuri

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Methods Mentioned

BETA
PCR
Chip

Software Mentioned

Brain Cloud
Scopus
ESME
of
Web
EMBASE

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