The role of oxytocin receptors and vasopressin V1a receptors in uterine contractions in rats: implications for tocolytic therapy with oxytocin antagonists

American Journal of Obstetrics and Gynecology
W Y ChanM Manning

Abstract

The objective of the study was to determine in the rat model whether the uterotonic action of vasopressin is mediated by the vasopressin V1a receptor in the uterus, by the oxytocin receptor, or by both. The purpose is to assess whether the anti-V1a activity of oxytocin antagonists is a desirable pharmacologic property in tocolytic therapy for preterm labor. Dose-response characteristics of the uterotonic action of oxytocin and arginine vasopressin were compared and analyzed by the in vitro cumulative dose-response curve technique. A nonselective oxytocin-V1a receptor antagonist, a selective oxytocin receptor antagonist, and a selective V1a receptor antagonist were selected for this study. Their relative effectiveness in inhibiting the uterine contractile responses induced by oxytocin and by arginine vasopressin in the isolated rat uterus was examined. The uterotonic dose-response curves for oxytocin and arginine vasopressin were parallel and had the same maximal response. The nonselective oxytocin/V1a receptor antagonist and the selective oxytocin receptor antagonist were equally potent in inhibiting the uterine contractions induced by either oxytocin or arginine vasopressin, whereas the selective V1a receptor antagonist had no...Continue Reading

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Citations

Jun 4, 2014·Journal of Neuroendocrinology·S Arrowsmith, S Wray
Oct 6, 2001·Journal of Peptide Science : an Official Publication of the European Peptide Society·M ManningW Y Chan
May 10, 2005·Journal of Peptide Science : an Official Publication of the European Peptide Society·Maurice ManningClaude Barberis
Feb 13, 2001·The Journal of Peptide Research : Official Journal of the American Peptide Society·E LempickaB Lammek
Jul 23, 2003·European Journal of Pharmacology·Masaki KawamataKatsuhiko Nishimori

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