The role of P-selectin, sialyl Lewis X and sulfatide in myocardial ischemia and reperfusion injury

European Journal of Pharmacology
K YamadaS Morooka

Abstract

The role of P-selectin and the ligands of selectins such as sialyl Lewis X and sulfatide was studied in a myocardial ischemia and reperfusion injury model. Anesthetized rabbits underwent the occlusion of coronary artery (30 min) followed by reperfusion (5 h). The inhibitory effect on myocardial ischemia and reperfusion injury was examined with infarct size normalized by area-at-risk. Intravenous administration of an anti-P-selectin monoclonal antibody, PB1.3 (2 mg/kg), reduced infarct size by 38%. Similarly, the administration of sialyl Lewis X-oligosaccharide (10 mg/kg) reduced infarct size by 53% significantly. Finally, the infarct size was significantly reduced bv 39% in sulfatide-treated group (10 mg/kg). These results suggest that P-selectin plays an important role in myocardial ischemia and reperfusion injury and that the ligands of selectins, such as sialyl Lewis X-oligosaccharide and sulfatide, have cardioprotective effect on myocardial ischemia and reperfusion injury.

References

Jul 1, 1992·Journal of Leukocyte Biology·G TodderudK M Tramposch
Oct 1, 1992·The Journal of Clinical Investigation·M S MulliganP A Ward
Feb 1, 1991·The Journal of Cell Biology·K D PatelT M McIntyre
Oct 1, 1991·The Journal of Clinical Investigation·M S MulliganP A Ward
Jan 1, 1990·Annual Review of Physiology·B R Lucchesi
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M P BevilacquaM A Gimbrone
Jan 3, 1994·European Journal of Pharmacology·D AltavillaA P Caputi
Feb 1, 1995·The Journal of Experimental Medicine·K LeyA L Beaudet
Jan 29, 1993·Biochemical and Biophysical Research Communications·Y SuzukiK Tadano-Aritomi
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·L K Needham, R L Schnaar
Oct 1, 1993·The Journal of Clinical Investigation·R K WinnJ M Harlan
Mar 1, 1994·The Journal of Clinical Investigation·M BuerkeA M Lefer
Jul 1, 1995·International Immunology·M S MulliganT Suzuki
Sep 1, 1996·Immunopharmacology·M OhnishiS Morooka

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Citations

May 20, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Kazuto YamadaNaohito Ohashi
Jan 5, 2002·European Journal of Pharmacology·Michał KurzelewskiAndrzej Beresewicz
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·D J Lefer
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Anil Nigam, Stephen L Kopecky
Oct 12, 2007·Biochimica Et Biophysica Acta·Susheel Gundewar, David J Lefer
Aug 20, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·K BuschardU Lindblad
Sep 27, 2005·European Journal of Pharmacology·Kazuto YamadaNaohito Ohashi
Aug 11, 2005·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Tanja BarkhausenMartijn van Griensven
Jan 27, 2007·The Journal of Surgical Research·Fernando López-Neblina, Luis H Toledo-Pereyra
Dec 17, 2008·Current Opinion in Pharmacology·Simon KennedySusan Pyne
Feb 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Luiz C GodoyJoan B Mannick

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