The role of p21-activated kinases in pancreatic cancer

Pancreas
Dannel YeoMehrdad Nikfarjam

Abstract

Pancreatic cancer is an aggressive cancer with a poor prognosis and an overall 5-year survival rate of less than 5%. Management has not improved significantly over the last 30 years, and a better understanding of the genetic and molecular changes that occur is urgently required. Many of these changes appear to involve the p21-activated kinases (PAKs). The PAK family consists of 6 isoforms, 2 of which, PAK1 and PAK4, are up-regulated and/or hyperactivated in pancreatic cancer. p21-Activated kinases can mediate many different cellular processes especially those contributing to cancer development and progression. These processes include the regulation of cytoskeletal dynamics and cell adhesion, the evasion of apoptosis, and the promotion of cell survival, proliferation, migration, and invasion. p21-Activated kinases may also be involved in characteristics unique to pancreatic tumors, such as interplay with the pancreatic stroma, the re-emergence of embryonic pathways, and the involvement of a subset of microRNAs and heat shock proteins. This review highlights the potential role of PAKs in pancreatic cancer and provides a foundation for more effective therapeutics to improve our current treatment of pancreatic cancer.

Citations

Mar 31, 2016·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Dannel YeoMehrdad Nikfarjam
Apr 28, 2016·Bioorganic & Medicinal Chemistry Letters·Jeung Kuk ParkSangYoun Park
Apr 28, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S JagadeeshanS K Rayala
Sep 23, 2016·Expert Opinion on Therapeutic Targets·Sankar JagadeeshanSuresh K Rayala
Jan 22, 2017·International Journal of Cancer. Journal International Du Cancer·Dannel YeoMehrdad Nikfarjam
May 31, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sehhoon ParkHo-Seong Han
Dec 7, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Irene Ramos-AlvarezR T Jensen
Jul 6, 2017·Oncology Reports·Xianghe LuWenfeng Li
Dec 14, 2016·BioMed Research International·Hang YinHailin Liu
Sep 30, 2018·Virchows Archiv : an International Journal of Pathology·Jinnian Ge, Chunlin Ge
Feb 14, 2019·Experimental & Molecular Medicine·So-Yoon WonEung-Gook Kim
Sep 27, 2019·Experimental and Therapeutic Medicine·Zailong Zhou, Jian Ma
Apr 12, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Lily NguyenStephanie E Combs
May 20, 2021·Journal of Cellular and Molecular Medicine·Antti M HaapalainenMika Rämet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Cellular Logistics
Diana Zi Ye, Jeffrey Field
Cancer Metastasis Reviews
Bettina DummlerJeffrey Field
International Review of Cell and Molecular Biology
Helen KingClaire M Wells
Hepatobiliary & Pancreatic Diseases International : HBPD INT
Wan-Yee Lau, Eric C H Lai
© 2021 Meta ULC. All rights reserved