The role of p27kip1 protein expression on the biological behavior of intrahepatic cholangiocarcinoma

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
K TaguchiMasazumi Tsuneyoshi

Abstract

Recent studies have reported that a decreased p27kip1 protein (p27) expression is associated with aggressive tumor behavior in several human malignancies. In this study, we examined the role of p27 expression in intrahepatic cholangiocarcinoma (ICC) and the noncancerous intrahepatic bile duct epithelium and assessed its association with clinicopathologic features, especially the influence of decreased p27 expression by the tumor on its prognosis as determined by immunohistochemistry. Almost all noncancerous bile duct epithelia show positive nuclear staining and reveal a faintly positive reaction in the cytoplasm. In 62 surgically resected ICCs, a variable degree of positive p27 nuclear staining is recognized. A subset (13 of 62 cases; 21.0%) of the carcinomas displayed cytoplasmic staining. We classified 62 cases into 2 groups, a low expression group (< 50% of p27 nuclear positive cells) and a high expression group (> or = 50% of p27 nuclear positive cells), and tested for the association between positive expression and clinicopathologic features. We found that a low expression of nuclear p27 was correlated with positive vascular invasion (P < .05). The survival curve of the group with low p27 nuclear expression was significant...Continue Reading

Citations

May 24, 2007·Journal of Hepato-biliary-pancreatic Surgery·Kohji NagataSuguru Yonezawa
Jul 23, 2005·Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology·Hatice TigliNejat Dalay
Oct 2, 2013·Annals of Surgical Oncology·Anthony T RuysThomas M van Gulik
Feb 12, 2014·Clinical Colorectal Cancer·Crystal S DenlingerSteven J Cohen
Nov 26, 2013·Clinics in Laboratory Medicine·Michael WeindelVinod B Shidham
Oct 22, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Christopher D BriggsDavid P Berry
Apr 23, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Takahiro TerashiMasazumi Tsuneyoshi
Jan 31, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hiroaki ShibaharaSuguru Yonezawa
Nov 16, 2004·Cancer Detection and Prevention·Takashi MaedaSuzanne M de la Monte
Nov 28, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hideaki TsutsumidaSuguru Yonezawa
Feb 11, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jian LuoHongzhen Lan
Jul 9, 2016·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·James GigrichThomas Holzer
Mar 25, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A GardiniA D'Errico Grigioni
Mar 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William R JarnaginBhuvanesh Singh
May 5, 2016·Technology in Cancer Research & Treatment·Chunxiang LiZheng Jiang
Apr 3, 2002·International Journal of Surgical Pathology·Shin-ichi AishimaMasazumi Tsuneyoshi
Jul 14, 2004·Physics in Medicine and Biology·Katsuyuki TaguchiMichael D Silver
Jul 22, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shugo TamadaSuguru Yonezawa

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