The role of P2X7 receptors in tissue fibrosis: a brief review

Purinergic Signalling
Daniela GentileFranco Laghi-Pasini

Abstract

Many previous studies have demonstrated that P2X(7) receptors (P2X(7)Rs) have a pleiotropic function in different pathological conditions and could represent a novel target for the treatment of a range of diseases. In particular, recent studies have explored the role of P2X(7)R in fibrosis, the pathological outcome of most chronic inflammatory diseases. The aim of this review is to discuss the biological features of P2X(7)R and summarize the current knowledge about the putative role of the P2X(7)R in triggering fibrosis in a wide spectrum of organs such as the lung, kidney, liver, pancreas, and heart.

References

Jun 1, 1995·The New England Journal of Medicine·M L SteerS Freedman
Oct 1, 1996·The European Journal of Neuroscience·G BuellF Rassendren
Feb 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A CasiniC Surrenti
Feb 3, 1997·The Journal of Experimental Medicine·D FerrariF Di Virgilio
Nov 19, 1997·Neuropharmacology·G ColloG Buell
Jun 17, 1999·Cell and Tissue Research·U Gröschel-StewartG Burnstock
Aug 10, 1999·Journal of Gastroenterology and Hepatology·D Li, S L Friedman
Mar 15, 2000·Gut·R C Benyon, J P Iredale
Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J M Sanz, F Di Virgilio
Aug 30, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·B EckesT Krieg
May 9, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A GartlandW B Bowler
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L C DenlingerP J Bertics
Aug 25, 2001·The New England Journal of Medicine·T J Gross, G W Hunninghake
May 4, 2002·Nature Reviews. Molecular Cell Biology·James J TomasekRobert A Brown
Sep 25, 2002·Physiological Reviews·R Alan North
Dec 20, 2002·Nature·Carl Nathan
Dec 24, 2002·The Journal of Biological Chemistry·Megan L SmartSteven Petrou
Feb 20, 2003·Journal of Hepatology·Scott L Friedman
Feb 26, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ramón BatallerDavid A Brenner
Jul 8, 2003·The Journal of Pathology·G Gabbiani
Sep 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Odette ViñasJuan Rodés
Nov 14, 2003·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Robert J UnwinGeoffrey Burnstock
Feb 10, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ali CanbayGregory J Gores
Mar 10, 2004·Biochemical Pharmacology·Joshua A McCarrollMinoti V Apte
Apr 2, 2004·Nephron. Physiology·M A BaileyR J Unwin
Jun 9, 2004·Biochemical and Biophysical Research Communications·Zhongming ChenLin Liu
Jun 11, 2004·Nature·Sanjeev MariathasanVishva M Dixit
Nov 19, 2004·International Review of Cytology·Geoffrey Burnstock, Gillian E Knight
Feb 3, 2005·American Journal of Physiology. Renal Physiology·D G ShirleyR J Unwin
Feb 4, 2005·The Journal of Clinical Investigation·Ramón Bataller, David A Brenner
Mar 2, 2006·Pharmacological Reviews·Geoffrey Burnstock
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Davide FerrariFrancesco Di Virgilio
Aug 22, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Beat M KünzliSimon C Robson
Oct 19, 2006·Journal of Molecular and Cellular Cardiology·Zhi-Sheng JiangElissavet Kardami
Dec 23, 2006·Nature Reviews. Immunology·Sanjeev Mariathasan, Denise M Monack
Mar 22, 2007·Cellular and Molecular Life Sciences : CMLS·G Burnstock
Sep 12, 2007·Trends in Immunology·Anna Rubartelli, Michael T Lotze
Nov 27, 2007·Gastroenterology·Beat M KünzliSimon C Robson

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Citations

Mar 6, 2019·Clinical and Experimental Pharmacology & Physiology·Camila Guerra Martinez
Feb 23, 2018·Science Translational Medicine·Naoki TakemuraSatoshi Uematsu
Nov 23, 2017·Purinergic Signalling·Geoffrey Burnstock, Gillian E Knight
Feb 23, 2018·Frontiers in Pharmacology·Luiz E B SavioRobson Coutinho-Silva
Sep 25, 2019·Journal of Cardiovascular Development and Disease·Jianlin FengLixia Yue
Oct 11, 2017·Frontiers in Pharmacology·Geoffrey Burnstock
Dec 19, 2019·Cells·Hong-Tai TzengWei-Yu Chen
Jan 2, 2021·International Journal of Molecular Sciences·Katarina AndelovaNarcis Tribulova
Nov 9, 2020·Biochemical Pharmacology·Amir Pelleg
Jul 31, 2021·Autonomic Neuroscience : Basic & Clinical·Christopher H Fry, Karen D McCloskey

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