The role of p38 MAPK in valproic acid induced microglia apoptosis

Neuroscience Letters
Nanchang XieZhaofu Chi

Abstract

Valproic acid (VPA), a widely prescribed drug for seizures and bipolar disorder, induces apoptosis in microglia, but the underlying mechanism by which microglia apoptosis in response to VPA is not yet known. In this study, we found that the mitochondrial pathway played an important role in VPA-induced apoptosis in both BV-2 microglia and mouse primary microglial cells. In addition, VPA increased the level of phospho-p38 mitogen-activated protein kinase (MAPK), but had no effects on phospho-ERK and phospho-JNK MAPKs. Moreover, p38 inhibitor SB203580 strongly inhibited VPA-induced apoptosis and caspase-3 activation. Taken together, our results clearly demonstrated that VPA could induce apoptosis of microglia via p38 MAPK and mitochondrial apoptosis pathway.

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Citations

Dec 22, 2015·Neurotoxicology·Long-Long YangGui-Rong Ding
May 31, 2012·Journal of Biochemical and Molecular Toxicology·Haiyang LiJunle Qu
Dec 12, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Li YuanXuebo Liu
Oct 18, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Michal BitmanPetr Pavek
May 13, 2018·Fundamental & Clinical Pharmacology·Iat-Lon LeongYuk-Man Leung
Aug 9, 2021·Environmental Science and Pollution Research International·Fatma AliHassan Ahmed

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis