The role of paliperidone extended release for the treatment of bipolar disorder.

Neuropsychiatric Disease and Treatment
Jehan MarinoCatherine Harrington

Abstract

Bipolar disorder (BD) is a chronic, relapsing, episodic mental illness associated with other psychiatric comorbidities. There is a substantial economic burden with BD, which makes it challenging to treat. The aim of this review is to evaluate the pharmacology, clinical efficacy, and safety data related to paliperidone extended release (ER) for the treatment of BD. A literature search was performed from January 1966 through January 2012 using PreMEDLINE, MEDLINE, EMBASE, IPA, and ClinicalTrials.gov to identify articles in English regarding the pharmacology, clinical efficacy, and safety of paliperidone ER in acute mania or mixed episodes or in the maintenance treatment of BD I. There are currently three published studies relating to the use of paliperidone ER for the treatment of BD. Two of these evaluated paliperidone ER as monotherapy for acute mania, while the other assessed its role as adjunct with a mood stabilizer. According to the limited available evidence, paliperidone at higher doses of ER 9-12 mg/day may be a safe and efficacious treatment option for acute episodes of mania in BD. A once-daily dose formulation may improve patient adherence to treatment; however, the cost of paliperidone ER, which is higher than that o...Continue Reading

References

Feb 1, 1994·Psychopharmacology·A A MegensJ E Leysen
Apr 10, 2002·Acta Psychiatrica Scandinavica·Ravi Lingam, Jan Scott
Nov 26, 2003·The American Journal of Psychiatry·Mauricio TohenRoss J Baldessarini
Jul 15, 2005·The Journal of Clinical Psychiatry·Roy H Perlis, Paul E Keck
Jan 30, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Marc VermeirAdriaan Cleton
Oct 15, 2009·International Journal of Clinical Pharmacology and Therapeutics·S BoomM Eerdekens
Feb 2, 2010·Psychosomatics·Jose de LeonNeil B Sandson
Mar 9, 2011·Archives of General Psychiatry·Kathleen R MerikangasZahari Zarkov

❮ Previous
Next ❯

Citations

Sep 19, 2012·Current Psychiatry Reports·Gin S MalhiMichael Berk
May 7, 2020·Frontiers in Endocrinology·Samantha Alvarez-HerreraLenin Pavón

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy
SGA
sedation

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here