The role of parenteral glutamine supplement for surgical patient perioperatively: result of a single center, prospective and controlled study.

Langenbeck's Archives of Surgery
Chun-Nan YehMiin-Fu Chen

Abstract

We conducted a prospective and case-controlled study to evaluate the impact of supplement of alanyl-glutamine dipeptide (Gln) in parenteral nutrition on perioperative immune and nutritional changes and clinical outcomes for patients undergoing gastrointestinal (GI) operations. During 2006, 70 patients undergoing GI surgeries were allocated equally into two groups. One group received regular parenteral nutrition and the other received the same formulation and supplemented with the Gln; the two groups were isonitrogenous. The infusion was started from 1 day before operation to the sixth day after operation for 7 days. Blood samples were collected on the morning of the day before the operation and on the morning 6 days after the operation and analyzed for immune and nutrition parameters. There were no differences between the two groups in terms of clinical characteristics, operative procedures, biochemistry, nutritional status, and immune status preoperatively. After GI surgery, significant reduction in nutritional and immune parameters were observed in both groups, demonstrated by significant difference of albumin, C-reactive protein (CRP), lymphocyte count, T cell, and CD8 cell. The length of hospital stay is slightly longer in ...Continue Reading

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Citations

Feb 16, 2013·The Proceedings of the Nutrition Society·Nikki BuijsPaul A M van Leeuwen
Nov 16, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Shadi S YarandiThomas R Ziegler
Dec 1, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Lea BollhalderMatthias Schwenkglenks
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Oct 11, 2019·Journal of Gastric Cancer·Ali Guner, Hyoung-Il Kim
Aug 28, 2020·Nutrients·Beata Jabłońska, Sławomir Mrowiec
Jul 28, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jin-Ming WuMing-Tsan Lin
Jul 3, 2021·JPEN. Journal of Parenteral and Enteral Nutrition·Maryam GholamalizadehSaeid Doaei

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