The Role of Parenteral Lipids in the Development of Hepatic Dysfunction and Hepatic Steatosis in a Mouse Model of Total Parenteral Nutrition

Journal of Nutritional Science and Vitaminology
Ziwei Xu, Yueming Sun

Abstract

Parenteral nutrition-associated liver disease, a common and life-threating complication among people who require long-term parenteral nutrition, has been associated with abnormal liver function, cholestasis, steatosis and fibrosis. Intravenous soybean lipids may be associated with the development of liver disease. We therefore examined whether different doses of parenteral lipids would affect the development of liver disease, and further investigated the possible pathogenesis of it. C57BL/6J mice with a central catheter placed in the right jugular vein were divided into three groups. The control group received normal mouse chow with intravenous normal saline; The lipids group received parenteral nutrition solution (0.14 g lipids per day); the H-lipids group received parenteral nutrition solution with twice the amount of lipids (0.3 g lipids per day). Changes in body weight, serum biochemical parameters, liver histology and farnesoid X receptor gene expression in the liver were assessed. The values of serum direct bilirubin, total bilirubin and cholesterol were markedly increased in the H-lipids group at day 7. The predominant histologic finding in the H-lipids group was steatosis, and the steatosis score in the H-lipids group w...Continue Reading

References

Nov 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·Z J ShuT H Zhang
Nov 9, 2000·JPEN. Journal of Parenteral and Enteral Nutrition·V ColombC Ricour
Aug 1, 1994·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Z J ShuJ S Li
May 4, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·Beth A Carter, Robert J Shulman
May 11, 2007·The American Journal of Clinical Nutrition·Geert J A Wanten, Philip C Calder
Mar 21, 2009·Current Opinion in Gastroenterology·Stefano Fiorucci, Franco Baldelli
Jul 2, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Linda P FriedKaren Bandeen-Roche
Jul 17, 2009·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Julie Slicker, Sarah Vermilyea
Apr 14, 2010·Current Opinion in Organ Transplantation·M Petrea Cober, Daniel H Teitelbaum
Oct 7, 2010·Early Human Development·Deirdre A Kelly
Nov 1, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ziwei XuJieshou Li
Jan 17, 2012·Journal of Pediatric Surgery·Shawn J RangelUNKNOWN 2011 American Pediatric Surgical Association Outcomes and Clinical Trials Committee
Jan 26, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Jing LiWei Cai
Oct 23, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Emma M Tillman
Dec 13, 2012·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Zi-Wei Xu, You-Sheng Li
Mar 20, 2016·JPEN. Journal of Parenteral and Enteral Nutrition·Gillian L FellMark Puder
Dec 29, 2016·Pediatric Surgery International·Noora H Al-Shahwani, David L Sigalet
Dec 29, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Kiran V K KoelfatSteven W M Olde Damink
Apr 25, 2017·Journal of Pediatric Gastroenterology and Nutrition·Michael SorrellCynthia Blanco
May 10, 2017·Nutrients·Barbara Bielawska, Johane P Allard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved