The role of particulate matter-associated zinc in cardiac injury in rats

Environmental Health Perspectives
Urmila P KodavantiAbraham Nyska

Abstract

Exposure to particulate matter (PM) has been associated with increased cardiovascular morbidity; however, causative components are unknown. Zinc is a major element detected at high levels in urban air. We investigated the role of PM-associated zinc in cardiac injury. We repeatedly exposed 12- to 14-week-old male Wistar Kyoto rats intratracheally (1x/week for 8 or 16 weeks) to a) saline (control); b) PM having no soluble zinc (Mount St. Helens ash, MSH); or c) whole-combustion PM suspension containing 14.5 microg/mg of water-soluble zinc at high dose (PM-HD) and d ) low dose (PM-LD), e) the aqueous fraction of this suspension (14.5 microg/mg of soluble zinc) (PM-L), or f ) zinc sulfate (rats exposed for 8 weeks received double the concentration of all PM components of rats exposed for 16 weeks). Pulmonary inflammation was apparent in all exposure groups when compared with saline (8 weeks > 16 weeks). PM with or without zinc, or with zinc alone caused small increases in focal subepicardial inflammation, degeneration, and fibrosis. Lesions were not detected in controls at 8 weeks but were noted at 16 weeks. We analyzed mitochondrial DNA damage using quantitative polymerase chain reaction and found that all groups except MSH caused...Continue Reading

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Datasets Mentioned

BETA
GSE6541

Methods Mentioned

BETA
chip
bronchoalveolar lavage
PCR
Assay
Protein Assay

Software Mentioned

R
LIMMA
AffylmGUI
bioconductor
Affymetrix
GeneSpring
microarray Suite
SPSS
SigmaStat

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