The role of PDE5 inhibitors in heme oxygenase-cGMP relationship in rat cavernous tissues

The Journal of Sexual Medicine
M Talaat Abdel AzizAhmed T Abdel Aziz

Abstract

Heme oxygenase (HO) enzyme catalyzes oxidative degradation of heme to biliverdin and carbon monoxide (CO). CO shares many properties with nitric oxide (NO) including the activation of soluble guanyl cyclase. To assess cavernous tissue HO activity and cyclic guanosine monophosphate (cGMP) levels in response to oral phosphodiesterase type 5 (PDE5) inhibitors. Seven hundred twenty male Sprague-Dawley rats, divided into six groups, were investigated. Group 1, controls; group 2 received sildenafil citrate orally; group 3 received vardenafil hydrochloride; and group 4 received tadalafil. Group 5 was subdivided into three equal subgroups, received the same dose of each drug added to the HO inhibitor, Zn protoporphyrin. Group 6 was subdivided into three equal subgroups, received the same dose of each drug added to the NO inhibitor, L-nitroarginine methylester. Eight rats from each group/subgroup were sacrificed at 0.5, 1, 2, 3, 4, 6, 18, 24, and 36 hours, respectively. HO enzyme activity assay and cGMP tissue levels in dissected rat cavernous tissues. Both cavernous tissue HO enzyme activity and cGMP levels were increased significantly in sildenafil-, vardenafil-, and tadalafil-treated rats compared with the controls, with significant ...Continue Reading

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Citations

Jun 25, 2010·International Journal of Impotence Research·T MostafaK Kotb
Mar 17, 2009·The Journal of Sexual Medicine·Nestor F Gonzalez-Cadavid
Jun 4, 2013·Urology·Mohamed E MostafaTaymour Mostafa
Jun 4, 2013·Urology·Mohamed E MostafaTaymour Mostafa
Jan 28, 2009·The Journal of Sexual Medicine·Mohamed T Abdel AzizDina Sabry
May 3, 2012·The Journal of Sexual Medicine·Mohamed Talaat Abdel AzizRaghda El-Shafiey
Jun 30, 2011·The Journal of Sexual Medicine·Mohamed Talaat Abdel AzizAhmed Abdel Aziz
Jan 14, 2009·The Journal of Sexual Medicine·Charalambos VlachopoulosChristodoulos Stefanadis
Sep 3, 2008·The Journal of Sexual Medicine·Taymour Mostafa
Oct 30, 2010·The Journal of Sexual Medicine·Arthur L BurnettZhong C Xin
Aug 8, 2014·International Journal of Impotence Research·A M S ZaahkoukM H Yehia
Oct 6, 2018·International Journal of Impotence Research·Taymour MostafaIngi A Mostafa
Oct 7, 2018·International Journal of Impotence Research·Taymour MostafaMaroa S Omar
Oct 31, 2020·International Journal of Pharmaceutics·Lamiaa R AbdelalimYosra S R Elnaggar

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