The role of pericytes in blood-brain barrier function and stroke

Current Pharmaceutical Design
Shuo LiuMark Fisher

Abstract

Central nervous system pericytes have critical and complex inductive, structural, and regulatory roles interacting with other cell types of the neurovascular unit, especially endothelial cells and astrocytes. Pericyte-endothelial interactions are particularly prominent for blood-brain barrier (BBB) maintenance, with profound effects on basement membrane and endothelial tight junction structure and function. Under experimental conditions of hypoxia-ischemia mimicking stroke, pericytes migrate from their usual microvascular location and influence, directly or indirectly, BBB permeability. The contractile properties of pericytes provide the capacity to regulate capillary blood flow, but this may have detrimental effects on ischemic injury. Stem cell characteristics of pericytes imply an important regenerative role following stroke. Pericytes thus appear to orchestrate multiple critical functions in stroke, involving blood flow, permeability, and repair of the neurovascular unit.

Citations

Oct 3, 2013·American Journal of Respiratory and Critical Care Medicine·Ivan O RosasPatricia J Sime
Apr 30, 2014·Archives of Toxicology·Márton JaniPéter Krajcsi
Apr 12, 2015·Brain Research·Yusuke EgashiraGuohua Xi
Jul 11, 2013·Mediators of Inflammation·Beatrice Mihaela RaduPaolo Francesco Fabene
Mar 6, 2015·Cell and Tissue Research·Lingling NengXiaorui Shi
Jun 21, 2014·Clinical Hemorheology and Microcirculation·Qingbin WuRuijuan Xiu
Sep 16, 2016·Frontiers in Endocrinology·Adonis SferaMichael Cummings
Nov 12, 2016·Translational Stroke Research·Wei CaiXiaoming Hu
Jun 3, 2017·Journal of the American Heart Association·Poornima VenkatJieli Chen
Jul 23, 2013·Circulation Research·Ornella Cappellari, Giulio Cossu
Oct 3, 2013·Stroke; a Journal of Cerebral Circulation·Mark J Fisher
Nov 1, 2018·American Journal of Physiology. Cell Physiology·Changjun YangEduardo Candelario-Jalil
Apr 16, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Paulo W PiresAnne M Dorrance
Dec 22, 2019·International Journal of Molecular Sciences·Eurydice AngeliGuilhem Bousquet
Jul 29, 2017·Angiogenesis·Henar CuervoChyuan-Sheng Lin
Nov 5, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Aniket S WadajkarAnthony J Kim
Jun 6, 2018·Proceedings of the National Academy of Sciences of the United States of America·Changsi CaiMartin J Lauritzen
Dec 22, 2019·International Journal of Molecular Sciences·Nunzia CaporarelloGabriella Lupo
Nov 11, 2017·The Journal of Clinical Endocrinology and Metabolism·Eugene J BarrettCarolina M Casellini
Jun 6, 2018·Journal of the Association for Research in Otolaryngology : JARO·Zhiqiang HouXiaorui Shi
Apr 23, 2020·Frontiers in Aging Neuroscience·Maiko T UemuraJohn Q Trojanowski
Feb 18, 2020·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Toshiaki NakanoTakanari Kitazono
Feb 14, 2021·Neurobiology of Aging·Eduardo Frías-AnayaIgnacio A Romero
Mar 9, 2021·Frontiers in Bioengineering and Biotechnology·Attilio MarinoGianni Ciofani

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