The Role of Periodic Limb Movements During Sleep in Restless Legs Syndrome: A Selective Update

Sleep Medicine Clinics
Stephany Fulda

Abstract

Periodic leg movements during sleep (PLMS) are a highly active research topic and accumulating recent evidence has led to reevaluation of key aspects on the role of PLMS in restless legs syndrome (RLS). This article summarizes the recent developments in 3 areas: the relationship of PLMS to cortical arousals in patients with RLS, the differential effect of dopaminergic and non-dopaminergic treatment on PLMS, and the possible emergence of PLMS as a sleep-related cardiovascular risk factor.

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Citations

Oct 21, 2016·Alcoholism, Clinical and Experimental Research·Subhajit ChakravortyKirk J Brower
Jun 16, 2017·Drugs·Susan E Mackie, John W Winkelman
May 15, 2021·Sleep Medicine Clinics·Stephany Fulda

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