The role of peripheral nerve fibers and their neurotransmitters in cartilage and bone physiology and pathophysiology

Arthritis Research & Therapy
Susanne Grässel

Abstract

The peripheral nervous system is critically involved in bone metabolism, osteogenesis, and bone remodeling. Nerve fibers of sympathetic and sensory origin innervate synovial tissue and subchondral bone of diathrodial joints. They modulate vascularization and matrix differentiation during endochondral ossification in embryonic limb development, indicating a distinct role in skeletal growth and limb regeneration processes. In pathophysiological situations, the innervation pattern of sympathetic and sensory nerve fibers is altered in adult joint tissues and bone. Various resident cell types of the musculoskeletal system express receptors for sensory and sympathetic neurotransmitters. Osteoblasts, osteoclasts, mesenchymal stem cells, synovial fibroblasts, and different types of chondrocytes produce distinct subtypes of adrenoceptors, receptors for vasointestinal peptide, for substance P and calcitonin gene-related peptide. Many of these cells even synthesize neuropeptides such as substance P and calcitonin gene-related peptide and are positive for tyrosine-hydroxylase, the rate-limiting enzyme for biosynthesis of catecholamines. Sensory and sympathetic neurotransmitters modulate osteo-chondrogenic differentiation of mesenchymal pro...Continue Reading

References

Jan 1, 1990·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·E M WojtysD Janda
Jan 1, 1988·Peptides·A BjurholmM Schultzberg
Aug 1, 1987·The Journal of Bone and Joint Surgery. British Volume·R Perkins, A P Skirving
May 6, 1983·European Journal of Pharmacology·H P Hartung, K V Toyka
Nov 1, 1995·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·B E Sherman, R A Chole
Sep 1, 1995·General Pharmacology·C A Maggi
Jun 1, 1994·Acta Orthopaedica Scandinavica·L NordslettenS Santavirta
Jan 1, 1996·Rheumatology International·T TanabeC Inagaki
Mar 11, 1999·Acta Anatomica·W Schwab, R H Funk
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L E MillerR H Straub
Mar 20, 2001·Journal of Cellular Biochemistry·M A Adamus, Z J Dabrowski
Mar 28, 2001·Annals of the New York Academy of Sciences·G J Maestroni
Oct 18, 2001·Clinical Orthopaedics and Related Research·A R PooleS Laverty
May 4, 2002·Stroke; a Journal of Cerebral Circulation·Kenneth E S PooleElizabeth A Warburton
Jul 13, 2002·Annals of the New York Academy of Sciences·S NiissaloY T Konttinen
Sep 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hisatomo KondoF Richard Bringhurst
Jan 16, 2003·Arthritis and Rheumatism·S J Millward-SadlerJ P Quinn
Nov 11, 2003·Neuropeptides·K Edoff, C Hildebrand
Nov 13, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Thorsten SchinkeMichael Amling
Jan 14, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sarah C OffleyWade S Kingery
Feb 23, 2005·Nature·Florent ElefteriouGerard Karsenty
Sep 1, 2005·Cellular and Molecular Life Sciences : CMLS·F Elefteriou
Sep 8, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C GomezC Chenu
Apr 21, 2007·Annals of the Rheumatic Diseases·Sunita SuriDavid A Walsh

❮ Previous
Next ❯

Citations

Sep 4, 2015·Osteoarthritis and Cartilage·J LorenzS Grässel
Oct 30, 2016·Archives of Oral Biology·Rizky Aditiya Irwandi, Anjalee Vacharaksa
Apr 30, 2017·International Journal of Molecular Sciences·Susanne Grässel, Dominique Muschter
Apr 15, 2018·Zeitschrift für Rheumatologie·H-G SchaibleR H Straub
Dec 12, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ceren TuzmenPhil Campbell
Nov 11, 2018·Journal of Cellular Physiology·Yini QiaoJuan Li
Jan 15, 2019·Tissue Engineering. Part B, Reviews·Sarah I M LepageThomas G Koch
Jan 22, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Daniela M SousaMeriem Lamghari
Mar 8, 2018·Molecular Medicine Reports·Suiyi WuJiangang Shi
Sep 4, 2020·Experimental Biology and Medicine·Bocun LiCai Guowei
May 11, 2018·Connective Tissue Research·Ceren Tuzmen, Phil G Campbell
Jun 3, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Éva BorbélyZsuzsanna Helyes
Jul 9, 2016·Journal of Translational Medicine·Daniel M VasconcelosMeriem Lamghari
Nov 5, 2016·Der Unfallchirurg·Burghard JacobyWolfgang Zinser
Sep 13, 2017·BMC Musculoskeletal Disorders·Manuel Ribeiro da SilvaMeriem Lamghari
Apr 22, 2018·Stem Cell Research & Therapy·Alessandro PirosaRocky S Tuan
Jun 17, 2018·Scientific Reports·Tanja NiedermairSusanne Grässel
Sep 20, 2018·Anatomical Science International·Jose Johann ChidiacNayef E Saadé
Apr 10, 2019·Proceedings. Biological Sciences·Valentina Di Santo
Jun 30, 2019·International Journal of Molecular Sciences·Karima El BagdadiZsuzsa Jenei-Lanzl
Mar 22, 2020·International Journal of Molecular Sciences·Johannes KupkaZsuzsa Jenei-Lanzl
Sep 16, 2020·International Journal of Molecular Sciences·Karin Wuertz-KozakPia M Wippert
Apr 3, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Tao ZhangHongbin Lu
Mar 18, 2020·Frontiers in Endocrinology·Fu-Xing-Zi LiLing-Qing Yuan
May 2, 2018·Frontiers in Veterinary Science·Olga KrupkovaAntonio Pozzi
Jan 18, 2019·International Journal of Molecular Sciences·Katarzyna D SluzalskaJuergen Steinmeyer
Jan 16, 2020·International Journal of Molecular Sciences·Tanja NiedermairSusanne Grässel
Jun 6, 2018·Frontiers in Bioengineering and Biotechnology·Sarah A WongChelsea S Bahney
Jul 25, 2018·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Birgitta Gatenholm, Mats Brittberg
Jun 27, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yangzi Jiang, Rocky S Tuan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.