Abstract
Peroxisome Proliferator-Activated Receptor-γ (PPARγ) is an extensively studied ligand-activated nuclear hormone receptor that functions as transcription factor and plays an important role in diverse biological processes, such as lipid metabolism and insulin sensitization. Recent studies have demonstrated that PPARγ is over-expressed in many tumor types, including breast cancer, suggesting a possible role in tumor development and/or progression and a putative prognostic value. Moreover, naturally-occurring and synthetic PPARγ agonists promote growth inhibition, apoptosis and differentiation of tumor cells. The present review summarizes the available information on PPARγ expression in breast tumors and the use of PPARγ ligands as anti-cancer agents for breast cancer treatment, both in vitro and in vivo. Considering the data so far, specific PPARγ agonists seem to exert beneficial effects against breast cancer and may therefore represent potential therapeutic agents.
Citations
Aug 25, 2016·Oncotarget·Daniela RovitoDaniela Bonofiglio
Dec 10, 2019·Current Cancer Drug Targets·Piotr Mrowka, Eliza Glodkowska-Mrowka
Nov 26, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Boyoung ParkEun-Sook Lee
Feb 1, 2014·Endocrine-related Cancer·Sarah A Dabydeen, Priscilla A Furth
Jul 3, 2019·Frontiers in Genetics·Simran KaurKulbhushan Sharma
Apr 19, 2015·Molecular Cancer·Anthony J ApostoliChristopher J B Nicol
Jul 13, 2016·Genome Medicine·Daniel SavicRichard M Myers
Dec 10, 2016·Oncotarget·Chin-Hsiao Tseng
Mar 10, 2017·Frontiers in Endocrinology·Veronica VellaRoberta Malaguarnera
Jul 4, 2018·International Journal of Molecular Sciences·Andrea AntonosanteAnnamaria Cimini
May 3, 2019·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Hassan R Dhaini, Zeina Daher
Sep 27, 2019·Breast Cancer : Basic and Clinical Research·Niamh O'HalloranAoife Lowery
Mar 8, 2014·Journal of Cellular Physiology·Alessio PapiMassimiliano Bonafé
Oct 6, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Luqi WangHiroki Yokota
Sep 18, 2020·Cancers·Giuseppina AugimeriDaniela Bonofiglio
Dec 31, 2020·Marine Drugs·Tzu-Yin HuangJyh-Horng Sheu
Oct 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Peng-Bo YangQiao Wu
Apr 20, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Xiaoyun TangDavid N Brindley
Mar 7, 2021·International Journal of Molecular Sciences·Anna TreboAnna Hester
Apr 4, 2021·International Journal of Environmental Research and Public Health·Pasquale SimeoneAnna M Giudetti
Jun 3, 2021·Biomedicines·Giuseppina Augimeri, Daniela Bonofiglio
Jul 28, 2016·Environmental Science & Technology·Pu XiaHongxia Yu